Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy

Yang, Yi; Zhang, Ping; Lü, Rong; He, Qiang; Zhu, Yuan; Yang, Xianghong; Chen, Jianghua

doi:10.1007/s00134-011-2319-9

Cited by 8 publications

(6 citation statements)

References 35 publications

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“…In the present study, we determined the mtDNA haplogroups of 312 agematched local Han men and found that the frequencies of the major Han mtDNA haplogroups (B, F, A, N9, D, G, M7, M8, M9) were similar to the published data. 20 This finding suggests that the lower frequency of mtDNA haplogroup R in asthenozoospermia patients is not related to geography and emphasizes the representation of the study cohort in the general population.…”

Section: Discussionmentioning

confidence: 73%

Mitochondrial DNA haplogroup associated with sperm motility in the Han population

Feng

Zhang²,

Lin³

et al. 2013

Asian J Androl

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In this study, we aimed to determine whether the main mitochondrial DNA (mtDNA) haplogroups of the Han people have an impact on spermatozoa motility. We recruited 312 men who were consecutively admitted to two affiliated hospitals of College of Medicine, Zhejiang University from May 2011 to April 2012 as part of fertility investigations. Semen and whole blood samples were collected from the men. We determined the mtDNA haplogroups by analysing the sequences of mtDNA hypervariable segment I and testing diagnostic polymorphisms in the mtDNA coding region with DNA probes. No significant differences were found in the clinical characteristics of the mtDNA haplogroup R and non-R (P .0.05). Our results suggest that mtDNA haplogroup R is a strong independent predictor of sperm motility in the Han population, conferring a 2.97-fold (95% confidence interval: 1.74-4.48, P,0.001) decreased chance of asthenozoospermia compared with those without haplogroup R.

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Section: Discussionmentioning

confidence: 73%

Mitochondrial DNA haplogroup associated with sperm motility in the Han population

Feng

Zhang²,

Lin³

et al. 2013

Asian J Androl

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“…The first is a synonymous polymorphism and the second is located in the control region but it does not affect important regions involved in regulation or transcription. Therefore, the association between R lineages and sepsis survival in Chinese patients [7,8] must be due to an over-representation of R sub-haplogroups, such as B or F, that are not present in the European population.…”

Section: Discussionmentioning

confidence: 99%

“…Thirteen subunits of the mitochondrial oxidative phosphorylation system, the major pathway of cellular energy production, are coded in mitochondrial DNA (mtDNA). Interestingly, in 137 and 181 septic patients from a Chinese Han population, mtDNA macrolineage R was found to be a strong independent predictor of sepsis survival at 30 days [7] and six-months [8], respectively. In China, this macrolineage is found in approximately 35% of the population and mainly includes haplogroups B and F. In Europe, the macrolineage R includes haplogroups that are different from those of Asia.…”

Section: Introductionmentioning

confidence: 99%

Severe Septic Patients with Mitochondrial DNA Haplogroup JT Show Higher Survival Rates: A Prospective, Multicenter, Observational Study

et al. 2013

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ObjectiveIn a previous cohort study (n=96), we found an association between mitochondrial (mt) DNA haplogroup JT and increased survival of severe septic patients, after controlling for age and serum lactic acid levels. The aim of this research was to increase the predictive accuracy and to control for more confounder variables in a larger cohort (n=196) of severe septic patients, to confirm whether mtDNA haplogroup JT influences short and medium-term survival in these patients.MethodsWe conducted a prospective, multicenter, observational study in six Spanish Intensive Care Units. We determined 30-day and 6-month survival and mtDNA haplogroup in this second cohort of 196 patients and in the global cohort (first and second cohorts combined) with 292 severe septic patients. Multiple logistic regression and Cox regression analyses were used to test for the association of mtDNA haplogroups JT with survival at 30-days and 6-months, controlling for age, sex, serum interleukin-6 levels and SOFA score.ResultsLogistic and Cox regression analyses showed no differences in 30-day and 6-month survival between patients with mtDNA haplogroup JT and other haplogroups in the first cohort (n=96). In the second cohort (n=196), these analyses showed a trend to higher 30-day and 6-month survival in those with haplogroup JT. In the global cohort (n=292), logistic and Cox regression analyses showed higher 30-day and 6-month survival for haplogroup JT. There were no significant differences between J and T sub-haplogroups in 30-day and 6-month survival.ConclusionsThe global cohort study (first and second cohorts combined), the largest to date reporting on mtDNA haplogroups in septic patients, confirmed that haplogroup JT patients showed increased 30-day and 6-month survival. This finding may be due to single nucleotide polymorphism defining the whole haplogroup JT and not separately for J or T sub-haplogroups.

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“…Therefore, mutations and polymorphisms of mitochondrial DNA might affect the cerebral response to sepsis. In a well-defined cohort of Chinese patients with sepsis, Yang et al [27] found that a haplogroup of mitochondrial DNA was a strong predictive factor for the development of septic encephalopathy. If confirmed in other populations, such findings pave the way for genomic research in the ICU.…”

Section: Epidemiologymentioning

confidence: 99%

Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals

et al. 2012

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Mitochondrial DNA haplogroup R in the Han population and recovery from septic encephalopathy

Cited by 8 publications

References 35 publications

Mitochondrial DNA haplogroup associated with sperm motility in the Han population

Mitochondrial DNA haplogroup associated with sperm motility in the Han population

Severe Septic Patients with Mitochondrial DNA Haplogroup JT Show Higher Survival Rates: A Prospective, Multicenter, Observational Study

Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals

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