Mitochondrial DNA Damage: Role of Ogg1 and Aconitase

Liu, Gang; Kamp, David W.

doi:10.5772/24362

Cited by 4 publications

(4 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The GGAA-duplication is contained in the regulatory region of the head-head configured ACO2/PHF5A genes [12]. The ACO2 encodes aconitase that functions in the TCA cycle to produce citrate and isocitrate and also serves as a mitochondrial redox-sensor [58]. More importantly, a recent study revealed that aconitase and mitochondrial base excision repair enzyme OGG1 (8-oxoguanine DNA glycosylase) cooperatively preserve mitochondrial DNA integrity [59].…”

Section: Identification Of Duplicated Ggaa (Ttcc) Motifs In the 5'-upmentioning

confidence: 99%

Transcriptional Regulation of the Human Genes that Encode DNA Repair- and Mitochondrial Function-Associated Proteins

Uchiumi¹,

Larsen²,

Tanuma³

2015

Advances in DNA Repair

View full text Add to dashboard Cite

Section: Identification Of Duplicated Ggaa (Ttcc) Motifs In the 5'-upmentioning

confidence: 99%

Transcriptional Regulation of the Human Genes that Encode DNA Repair- and Mitochondrial Function-Associated Proteins

Uchiumi¹,

Larsen²,

Tanuma³

2015

Advances in DNA Repair

View full text Add to dashboard Cite

“…The GGAA-duplication is contained in the regulatory region of the head-head configured ACO2/PHF5A genes [54]. The ACO2 gene encodes aconitase, which plays an important role in the TCA cycle to produce citrate and isocitrate, and which also serves as a mitochondrial redox-sensor [154]. Importantly, aconitase and mitochondrial BER enzyme OGG1 (8-oxoguanine DNA glycosylase) cooperatively preserve mitochondrial DNA integrity [155].…”

Section: The Localization Of P53 and Other Dna Repair Factors In The mentioning

confidence: 99%

A New Insight into the Development of Novel Anti-Cancer Drugs that Improve the Expression of Mitochondrial Function-Associated Genes

Uchiumi¹,

Arakawa²,

Takihara³

et al. 2018

Mitochondrial Diseases

View full text Add to dashboard Cite

Recent analyses of the whole genome sequencing data enable us to predict cancer incidence for healthy people at present. In addition, metabolome analyses rediscovered that "cancer is a metabolic disease". Importantly, it has been suggested that mitochondrial dysfunction might precede the metabolic change. In this chapter, we would discuss if "cancer is a transcriptional disease". Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells.

show abstract

“…E-mail: penny.nymark@ki.se (Huang et al, 2012). Mitochondria play a central role in regulating several key cellular functions, including apoptosis, glucose metabolism, maintenance of oxidant-antioxidant balance and cell cycle regulation, which is why their dysfunctions are related to a wide variety of human diseases, such as Alzheimer's and cardiovascular disease, as well as fibrosis and carcinogenesis, the two primary pathogenic effects of asbestos in humans (Antico Arciuch et al, 2012;Liu et al, 2013;Liu & Kamp, 2011;Nymark et al, 2008). Asbestos-induced mitochondrial dysfunction is thought to be related to apoptosis or to apoptotic bypass and an increased formation of reactive oxygen species (ROS), leading to a feedback loop between oxidative stress-activated gene expression and uncontrolled ROS formation (Huang et al, 2012;Nymark et al, 2008;Panduri et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells

et al. 2015

View full text Add to dashboard Cite

Understanding toxicity pathways of engineered nanomaterials (ENM) has recently been brought forward as a key step in twenty-first century ENM risk assessment. Molecular mechanisms linked to phenotypic end points is a step towards the development of toxicity tests based on key events, which may allow for grouping of ENM according to their modes of action. This study identified molecular mechanisms underlying mitochondrial dysfunction in human bronchial epithelial BEAS 2B cells following exposure to one of the most studied multi-walled carbon nanotubes (Mitsui MWCNT-7). Asbestos was used as a positive control and a non-carcinogenic glass wool material was included as a negative fibre control. Decreased mitochondrial membrane potential (MMP↓) was observed for MWCNTs at a biologically relevant dose (0.25 μg/cm(2)) and for asbestos at 2 μg/cm(2), but not for glass wool. Extensive temporal transcriptomic and microRNA expression analyses identified a 330-gene signature (including 26 genes with known mitochondrial function) related to MWCNT- and asbestos-induced MMP↓. Forty-nine of the MMP↓-associated genes showed highly similar expression patterns over time (six time points) and the majority was found to be regulated by two transcription factors strongly involved in mitochondrial homeostasis, APP and NRF1. In addition, four miRNAs were correlated with MMP↓ and one of them, miR-1275, was found to negatively correlate with a large part of the MMP↓-associated genes. Cellular processes such as gluconeogenesis, mitochondrial LC-fatty acid β-oxidation and spindle microtubule function were enriched among the MMP↓-associated genes and miRNAs. These results are expected to be useful in the identification of key events in ENM-related toxicity pathways for the development of molecular screening techniques.

show abstract

Mitochondrial DNA Damage: Role of Ogg1 and Aconitase

Cited by 4 publications

References 135 publications

Transcriptional Regulation of the Human Genes that Encode DNA Repair- and Mitochondrial Function-Associated Proteins

Transcriptional Regulation of the Human Genes that Encode DNA Repair- and Mitochondrial Function-Associated Proteins

A New Insight into the Development of Novel Anti-Cancer Drugs that Improve the Expression of Mitochondrial Function-Associated Genes

Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells

Contact Info

Product

Resources

About