Mitochondrial DNA D‐loop sequence analysis reveals high variation and multiple maternal origins of indigenous Tanzanian goat populations

Nguluma, Athumani Shabani; Kyallo, Martina; Tarekegn, Getinet Mekuriaw; Loina, Rose; Nziku, Zabron; Chenyambuga, Sebastian Wilson; Pellé, Roger

doi:10.1002/ece3.8265

Cited by 7 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Average diversity values of Hd and π were 0.889±0.000899 and 0.03005±0.00000008, respectively. These results were similar to haplotype and nucleotide diversity of Mongolian or Tanzanian indigenous goats (Ganbold et al, 2021;Nguluma et al, 2021) but haplotype and nucleotide divergence within the local goat population in our study was lower.…”

Section: Evaluation Of Genetic Diversity and Distancesupporting

confidence: 92%

“…The high level of mtDNA diversity of imported exotic goats in this study was due to the maternal effects of the forebears (Mannen et al, 2001). The proportion of transition/transversion was 25:1, indicating a strong bias of transition, higher than the 17:1 and 16.7:1 ratios documented in husbandry goat breeds (Luikart et al, 2001;Chen et al, 2005) or Indian local goats ( Joshi et al, 2004) but lower than in Tanzanian indigenous goats (28.7:1) reported by Nguluma et al (2021).…”

Section: Nucleotide and Haplotype Variationmentioning

confidence: 58%

“…Recently, investigations of domestic goats in Brazil (Silva et al, 2019) and Arabia (Al-Araimi et al, 2017) reported that most belonged to maternal lineage A. More than 90% of the world's goats were identified as belonging to lineage A (Wang et al, 2015;Deng et al, 2018;Ganbold et al, 2020;Nguluma et al, 2021). Maternal lineage B showed limited distribution and was only found on the Asian continent (southern and eastern areas), and in South Africa, while other lineages (C, G, F and D) were recorded in Southern Europe, Southwest Asia, Northern Africa and Italy, respectively (Pakpahan et al, 2016;Nguluma et al, 2021).…”

Section: Analysis Of Phylogenymentioning

confidence: 99%

See 2 more Smart Citations

Genetic Divergence of Local Goats in Ninh Thuan Province Vietnam

Nguyen¹,

Tram²,

Phạm³

et al. 2022

AAVS

View full text Add to dashboard Cite

The hypervariable region (D-loop) of mtDNA (mitochondrial DNA) of local goat breeds in Ninh Thuan Province, Vietnam was studied to provide useful information on their origin. Blood samples were taken from two local goat breeds in Ninh Thuan (De Co = CO and Bach Thao = BT, 10 samples each) and three other exotic goats including Saanen (SA; 10 samples), Red Boer (RB; 10 samples) and White Boer (WB; 9 samples) raised at An Phu Dairy Company in Cu Chi District, Ho Chi Minh City. Extracted mtDNA was used to amplify the fragment of 687 bp in the D-loop by polymerase chain reaction (PCR) followed by sequencing to analyze nucleotide polymorphism, haplotype diversity and genetic distance to construct a phylogram. Results showed that the fragment of 687 bp was successfully amplified. Examination of 49 sequence variants in 599 bp of the control region revealed the nucleotide composition was Adenine (A) = 32.55%, Thymine (T) = 28.33%, Guanine (G) = 14.67%, Cytosine (C) = 24.87% and G+C content was 39.12%. Out of a total of 50 nucleotide polymorphic sites, 48 were transition and 2 were transversion, with 21 haplotypes observed. Nucleotide and haplotype diversity indices (π and Hd) were 0.03005 and 0.889, respectively. The genetic diversity of Saanen goats was highest at (π) = 0.03031 and (Hd) = 0.987, while the lowest genetic diversity was found in Bach Thao goats (π = 0.00089 and Hd = 0.533). Genetic distance between WB and CO or BT was higher (0.058) than between RB and CO or BT (0.056 or 0.055). The lowest genetic distance was found between CO and BT goats (0.001). Most local goat breeds were grouped in one clade, with exotic goat breeds concentrated in other clade, indicating clear maternal divergence between local and exotic goat breeds. D-loop mtDNA diversity within the two local goat breeds in Ninh Thuan Province of Vietnam was low, indicating a close genetic relationship with Indochina goats (Laos), separated into a sub-lineage from maternal lineage B. Further insights regarding the genetic diversity of Vietnamese local goats require detailed in-depth studies.

show abstract

Section: Evaluation Of Genetic Diversity and Distancesupporting

confidence: 92%

Section: Nucleotide and Haplotype Variationmentioning

confidence: 58%

Section: Analysis Of Phylogenymentioning

confidence: 99%

See 1 more Smart Citation

Genetic Divergence of Local Goats in Ninh Thuan Province Vietnam

Nguyen¹,

Tram²,

Phạm³

et al. 2022

AAVS

View full text Add to dashboard Cite

show abstract

“…The mismatch distribution patterns were bimodal for the three Congolese indigenous goat populations. Similar demographic patterns have been observed in Tanzanian (Nguluma et al, 2021), Ethiopian (Tarekegn et al, 2018), and Oman indigenous goats (Al‐Araimi et al, 2017). The negative and significant ( p ‐value <.05) Tajima's D (−2.189) and Fu's D (−20.418) values supported population expansion for all the three Congolese indigenous goat populations.…”

Section: Discussionsupporting

confidence: 73%

“…Therefore, Bwihangane et al (2018) have found one individual from the Fizi goat population (0.9%) to be aligned to lineage B in the total individuals considered (110; 100%) in the study. Since Fizi is closed to Tanzania (eastern country) from where the haplogroup B was found in goat populations (Nguluma et al, 2021), the probability of having the goat aligned to the lineage B could be possible. Further investigation is required to confirm the presence of haplogroup B in Congolese indigenous goat populations in that area of South Kivu.…”

Section: Discussionmentioning

confidence: 99%

Haplotype analysis of the mitochondrial DNA d‐loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo

Simon

Jung'a

Tarekegn

et al. 2022

Ecology and Evolution

Self Cite

View full text Add to dashboard Cite

This study aimed at assessing haplotype diversity and population dynamics of three Congolese indigenous goat populations that included Kasai goat (KG), small goat (SG), and dwarf goat (DG) of the Democratic Republic of Congo (DRC). The 1169 bp d‐loop region of mitochondrial DNA (mtDNA) was sequenced for 339 Congolese indigenous goats. The total length of sequences was used to generate the haplotypes and evaluate their diversities, whereas the hypervariable region (HVI, 453 bp) was analyzed to define the maternal variation and the demographic dynamic. A total of 568 segregating sites that generated 192 haplotypes were observed from the entire d‐loop region (1169 bp d‐loop). Phylogenetic analyses using reference haplotypes from the six globally defined goat mtDNA haplogroups showed that all the three Congolese indigenous goat populations studied clustered into the dominant haplogroup A, as revealed by the neighbor‐joining (NJ) tree and median‐joining (MJ) network. Nine haplotypes were shared between the studied goats and goat populations from Pakistan (1 haplotype), Kenya, Ethiopia and Algeria (1 haplotype), Zimbabwe (1 haplotype), Cameroon (3 haplotypes), and Mozambique (3 haplotypes). The population pairwise analysis (FST) indicated a weak differentiation between the Congolese indigenous goat populations. Negative and significant (p‐value <.05) values for Fu's Fs (−20.418) and Tajima's (−2.189) tests showed the expansion in the history of the three Congolese indigenous goat populations. These results suggest a weak differentiation and a single maternal origin for the studied goats. This information will contribute to the improvement of the management strategies and long‐term conservation of indigenous goats in DRC.

show abstract

Ecogroups and maternal haplogroups reveal the ancestral origin of native Chinese goat populations based on the variation of mtDNA D‐loop sequences

Qin,

Chen,

Guo

et al. 2023

Ecology and Evolution

View full text Add to dashboard Cite

China is rich in goat breeding resources. Officially recognized local goat breeds are mainly distributed in agro‐ecological regions. The population structure and matrilineal origin of native Chinese goats can be used to formulate protection and utilization strategies for these genetic resources. In this study, the genetic structure and maternal origin of native Chinese goats were investigated using mtDNA D‐loop sequences. A total of 329 goat samples from 25 Chinese indigenous goat populations and five introduced goat breeds from abroad were collected; these populations were distributed in four ecogroups designated as Southwest, South‐central, the North China Plain, and Foreign‐ecogroup. A larger average number of nucleotide differences and richer nucleotide diversity were observed in South‐central and Foreign‐ecogroup, whereas these were lower in Southwest. The 216 haplotypes divided into several haplogroups, of which HapA contained 99 haplotypes distributed in Southwest, the North China Plain, and Foreign‐ecogroup with high frequency (0.53–0.77), whereas the frequency of HapA in South‐central was <0.09. HapB was mostly found in South‐central (0.5538) and was distributed to the North China Plain (0.2667), while it was rare in Southwest (<0.08) and Foreign‐ecogroup (<0.07). According to the estimation of kinship and ancestry, HapA had five ancestors (A2, A3, A5, A10, and A12), HapB had a single maternal ancestor (A8), and HapC had two maternal ancestors (A1 and A4). This study showed that native Chinese goat breeds were mainly divided into three haplogroups (HapA, HapB, and HapC) and goat populations have expanded in the ecological regions.

show abstract

Mitochondrial DNA D‐loop sequence analysis reveals high variation and multiple maternal origins of indigenous Tanzanian goat populations

Cited by 7 publications

References 34 publications

Genetic Divergence of Local Goats in Ninh Thuan Province Vietnam

Genetic Divergence of Local Goats in Ninh Thuan Province Vietnam

Haplotype analysis of the mitochondrial DNA d‐loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo

Ecogroups and maternal haplogroups reveal the ancestral origin of native Chinese goat populations based on the variation of mtDNA D‐loop sequences

Contact Info

Product

Resources

About