Mitochondrial DNA copy number in Mexican children co-exposed to inorganic arsenic and fluoride from Zacatecas, Mexico

Martínez-Acuña, Mónica; Mejía-Saavedra, Jesús; Peña, L.C. Sánchez; Matoušek, Tomáš; Razo, Luz María Del; Alegría-Torres, Jorge Alejandro

doi:10.1016/j.toxlet.2016.07.324

Cited by 1 publication

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“…Since total COEs-exposure levels is a comprehensive indicator of working time and working location, neither one of these can reflect exposure level alone. Moreover, several researches have shown that benzene and black carbon ( 19 ) could cause an increased mtDNA copy number and conversely, lead ( 30 ), elemental carbon and arsenic ( 31 ) could lead to a decreased mtDNA copy number. PAH, a known carcinogen and mutagen, has also been reported to be related with changes in mtDNA copy number, although the relationships are inconsistent.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Polymorphisms in Cell-Cycle Genes and Mitochondrial DNA Copy Number in Coke Oven Workers

Wang

Tan

Wang

et al. 2022

Front. Public Health

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The mitochondrial DNA (mtDNA) copy number is a vital component in maintaining normal mitochondrial function. It is affected by environmental and occupational exposures, as well as polymorphisms in nuclear genes. Nonetheless, the specific roles of polymorphisms in cell-cycle genes and mtDNA copy number are still unknown. This study enrolled a sample of 544 coke oven workers and 238 non-exposed controls so as to assess the effect of exposure of coke oven emissions (COEs) and polymorphisms in cell-cycle genes on the mtDNA copy number. We found that the mtDNA copy number in the exposed group (0.60 ± 0.29) was significantly lower than that in the control group (1.03 ± 0.31) (t =18.931, P < 0.001). The analysis of covariance showed that both the rs1801270 (CA+CC) and the rs1059234 (CT+CC) in p21 gene were associated with lower mtDNA copy number in the exposed group (P = 0.001). Generalized linear models indicated COEs-exposure (β = −0.432, P < 0.001) and rs1059234 (CT+CC) in p21 gene (β = −0.060, P = 0.024) were the factors in mtDNA copy number reduction. In conclusion, this study suggests that the decrease of the mtDNA copy number is associated with COEs-exposure and the rs1059234 (CT+CC) in the p21 gene.

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Section: Discussionmentioning

confidence: 99%