Mitochondrial DNA and Y Chromosome-Specific Polymorphisms in the Seminole Tribe of Florida

Huoponen, Kirsi; Torroni, Antonio; Wickman, Patricia R.; Sellitto, Daniele; Gurley, Daniel S.; Scozzarzi, Rosaria; Wallace, Douglas C.

doi:10.1159/000484728

Cited by 27 publications

(26 citation statements)

References 13 publications

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“…This model is generally consistent with the age of and patterns of diversity in A2z and A2* in Puerto Rico and Cuba. However, given the limited number and low resolution of indigenous mtDNA data from indigenous Floridians and the American Southeast (Huoponen et al, ; Bolnick and Smith, ), which undoubtedly were reshaped by the population losses and dislocations resulting from the 1539‐42 De Soto expedition (Galloway, ) and others following it, we can only speculate about Florida possibly being a place of origin for A2z and A2* at this time.…”

Section: Discussionmentioning

confidence: 93%

Genetic diversity inPuertoRico and its implications for the peopling of theIsland and theWestIndies

Vilar

Melé

Sanders

et al. 2014

American J Phys Anthropol

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Puerto Rico and the surrounding islands rest on the eastern fringe of the Caribbean's Greater Antilles, located less than 100 miles northwest of the Lesser Antilles. Puerto Ricans are genetic descendants of pre-Columbian peoples, as well as peoples of European and African descent through 500 years of migration to the island. To infer these patterns of pre-Columbian and historic peopling of the Caribbean, we characterized genetic diversity in 326 individuals from the southeastern region of Puerto Rico and the island municipality of Vieques. We sequenced the mitochondrial DNA (mtDNA) control region of all of the samples and the complete mitogenomes of 12 of them to infer their putative place of origin. In addition, we genotyped 121 male samples for 25 Y-chromosome single nucleotide polymorphism and 17 STR loci. Approximately 60% of the participants had indigenous mtDNA haplotypes (mostly from haplogroups A2 and C1), while 25% had African and 15% European haplotypes. Three A2 sublineages were unique to the Greater Antilles, one of which was similar to Mesoamerican types, while C1b haplogroups showed links to South America, suggesting that people reached the island from the two distinct continental source areas. However, none of the male participants had indigenous Y-chromosomes, with 85% of them instead being European/Mediterranean and 15% sub-Saharan African in origin. West Eurasian Y-chromosome short tandem repeat haplotypes were quite diverse and showed similarities to those observed in southern Europe, North Africa and the Middle East. These results attest to the distinct, yet equally complex, pasts for the male and female ancestors of modern day Puerto Ricans.

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Section: Discussionmentioning

confidence: 93%

Genetic diversity inPuertoRico and its implications for the peopling of theIsland and theWestIndies

Vilar

Melé

Sanders

et al. 2014

American J Phys Anthropol

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“…and Seminoles (Huoponen et al 1997). Allele 18, the most common Native American DYS1 allele, was observed in 20 of 55 individuals, and was always found on chromosomes containing the DYS199 T allele.…”

Section: Distribution Of Y Chromosome Polymorphismsmentioning

confidence: 96%

Y chromosome polymorphisms in Native American and Siberian populations: identification of Native American Y chromosome haplotypes

et al. 1997

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We have initiated a study of ancient male migrations from Siberia to the Americas using Y chromosome polymorphisms. The first polymorphism examined, a C→T transition at nucleotide position 181 of the DYS199 locus, was previously reported only in Native American populations. To investigate the origin of this DYS199 polymorphism, we screened Y chromosomes from a number of Siberian, Asian, and Native American populations for this and other markers. This survey detected the T allele in all five Native American populations studied at an average frequency of 61%, and in two of nine native Siberian populations, the Siberian Eskimo (21%) and the Chukchi (17%). This finding suggested that the DYS199 T allele may have originated in Beringia and was then spread throughout the New World by the founding populations of the major subgroups of modern Native Americans. We further characterized Native American Y chromosome variation by analyzing two additional Y chromo-some polymorphisms, the DYS287 Y Alu polymorphic (YAP) element insertion and a YAP-associated A→G transition at DYS271, both commonly found in Africans. We found neither African allele associated with the DYS199 T allele in any of the Native American or native Siberian populations. However, we did find DYS287 YAP+ individuals who harbored the DYS199 C allele in one Native American population, the Mixe, and in one Asian group, the Tibetans. A correlation of these Y chromosome alleles in Native Americans with those of the DYS1 locus, as detected by the p49a/p49f (p49a,f) probes on TaqI-digested genomic DNA, revealed a complete association of DYS1 alleles (p49a,f haplotypes) 13, 18, 66, 67 and 69 with the DYS199 T allele, while DYS1 alleles 8 and 63 were associated with both the DYS199 C and T allele.

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“…Recently, a fifth founding haplogroup, termed haplogroup X, was confirmed in a number of studies (Bailliet et al, 1994;Forster et al, 1996;Scozzari et al, 1997;Smith et al, 1999). With the exception of some Canadian Ojibwa (i.e., those who were studied in this large geographically dispersed population), in which haplogroup X is relatively frequent , this haplogroup is rare among modern Native Americans (around 3%; Smith et al 1999), and has not been found in relevant southeastern tribes, such as the Seminole, Cherokee, and Creek (Huoponen et al, 1997;Smith et al, 1999). Thus, an estimate of maternal Native American contribution in South Carolina African Americans can be calculated simply as the total percentage of Native American haplogroups observed in the samples.…”

Section: European Genetic Contribution To South Carolina African-amermentioning

confidence: 99%

Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina

Parra

Kittles

Argyropoulos

et al. 2001

Am. J. Phys. Anthropol.

231

149

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We analyzed admixture in samples of six different African-American populations from South Carolina: Gullah-speaking Sea Islanders in coastal South Carolina, residents of four counties in the "Low Country" (Berkeley, Charleston, Colleton, and Dorchester), and persons living in the city of Columbia, located in central South Carolina. We used a battery of highly informative autosomal, mtDNA, and Y-chromosome markers. Two of the autosomal markers (FY and AT3) are linked and lie 22 cM apart on chromosome 1. The results of this study indicate, in accordance with previous historical, cultural, and anthropological evidence, a very low level of European admixture in the Gullah Sea Islanders (m = 3.5 +/- 0.9%). The proportion of European admixture is higher in the Low Country (m ranging between 9. 9 +/- 1.8% and 14.0 +/- 1.9%), and is highest in Columbia (m = 17.7 +/- 3.1%). A sex-biased European gene flow and a small Native American contribution to the African-American gene pool are also evident in these data. We studied the pattern of pairwise allelic associations between the FY locus and the nine other autosomal markers in our samples. In the combined sample from the Low Country (N = 548), a high level of linkage disequilibrium was observed between the linked markers, FY and AT3. Additionally, significant associations were also detected between FY and 4 of the 8 unlinked markers, suggesting the existence of significant genetic structure in this population. A continuous gene flow model of admixture could explain the observed pattern of genetic structure. A test conditioning on the overall admixture of each individual showed association of ancestry between the two linked markers (FY and AT3), but not between any of the unlinked markers, as theory predicts. Thus, even in the presence of genetic structure due to continuous gene flow or some other factor, it is possible to differentiate associations due to linkage from spurious associations due to genetic structure.

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Mitochondrial DNA and Y Chromosome-Specific Polymorphisms in the Seminole Tribe of Florida

Cited by 27 publications

References 13 publications

Genetic diversity inPuertoRico and its implications for the peopling of theIsland and theWestIndies

Genetic diversity inPuertoRico and its implications for the peopling of theIsland and theWestIndies

Y chromosome polymorphisms in Native American and Siberian populations: identification of Native American Y chromosome haplotypes

Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina

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