Mitochondrial Deoxyribonucleic Acid Copy Number Elevation As a Predictor for Extended Survival and Favorable Outcomes in High-Grade Brain Tumor Patients: A Malaysian Study
Siti Muslihah Ab Radzak,
Siti Zulaikha Nashwa Mohd Khair,
Zamzuri Idris
et al.
Abstract:Background:
Investigating the role of mitochondrial DNA (mtDNA) alterations and their impact on brain tumor progression remains a significant focus in cancer research. The research aimed to explore the specific contributions of mtDNA copy number changes and their correlations with patient survival, large mtDNA deletions, and
TFAM
mutations in brain tumor patients.
Methods:
A total of 41 patients with confirmed brain tumors underwent DNA extrac… Show more
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