Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy

He, Tao; Guan, Aili; Shi, Yue; Ge, Zhiming; Dai, Hongji

doi:10.1007/s00059-015-4301-8

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…[ 29 ] In addition, hesperidin can be cardioprotective by downregulating the expression levels of proteins known to affect blood pressure, such as ATP5PF (−1.61‐fold), which is found in kidney tissue and related to vasoconstriction, hypertension, and cardiac hypertrophy in rats and humans. [ 30,31 ] Another related protein that appeared to be downregulated in the kidney tissues of MS rats was TPT1 (−1.44‐fold). TPT is implicated in the pathogenesis of atherosclerosis and pulmonary artery hypertension to prevent macrophage apoptosis in the artery intima.…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

Pla‐Pagà

Guirro

Gual‐Grau

et al. 2020

Molecular Nutrition Food Res

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Scope: Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats. Methods and results: 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg −1 day −1 ), MS rats without HS, and MS rats administered with HS (100 mg kg −1 day −1 ) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases. Conclusion: This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.

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Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

Pla‐Pagà

Guirro

Gual‐Grau

et al. 2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function

Zhao,

Yang,

Liu

et al. 2024

Mol Cell Biochem

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Danhong injection attenuates isoproterenol-induced cardiac hypertrophy by regulating p38 and NF-κb pathway

Mao

Wang

YunHang

et al. 2016

Journal of Ethnopharmacology

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Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy

Abstract: CF6 protein was upregulated in cardiac hypertrophy induced by hypertension; further mechanisms involved in this process should be investigated.

Cited by 3 publications

References 26 publications

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic Syndrome Rats after Hesperidin Supplementation

Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function

Danhong injection attenuates isoproterenol-induced cardiac hypertrophy by regulating p38 and NF-κb pathway

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