“…Polyamine, putrescin and asparagine metabolism are known to be strongly altered in cancer [59][60][61]. Metabolism of amino acids, polyamines, ornithine and taurine are all strongly inter-connected, and their expression was in fact found significantly altered in Table 1 (see lines n. 6,8,18,19,20,23,35,39,41,42,52,54,59 and 79) indicating a profound metabolism alteration of all amino acids and proteins. Finally, choline-related metabolism was found modified in Table 1 (see line n. 16, 57, 58, 60, 61, 63, 64, 65, 66 70, 71, 73, 74, 75 and 76), indicating a significant effect of miconazole on an essential molecule in phospholipids structure as well as in neurotransmitters, linked to betaine metabolism [62] and to fatty acids synthesis, which were in fact significantly modified in Table 1 at lines n. 12, 17, 38, 51, 82.…”