Mitochondrial cAMP signaling

Zhang, Fan; Zhang, Liping; Qi, Yun; Xu, Hong

doi:10.1007/s00018-016-2282-2

Cited by 91 publications

(75 citation statements)

References 149 publications

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“…The G iα subunit can activate ERK1/2 primarily through inhibiting AC and altering Ras-dependent. The inhibited AC activity can decrease the cAMP level and PKA activity (F. Zhang et al, 2016). This process will activate Ras, the upstream molecule of C-Raf (Goldsmith & Dhanasekaran, 2007).…”

Section: Erk1/2 Signaling Pathwaymentioning

confidence: 99%

The roles of GRP81 as a metabolic sensor and inflammatory mediator

Cai

Liu

et al. 2020

Journal Cellular Physiology

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GPR81 (also named as HCA1) is a member of a subfamily of orphan G‐protein coupled receptors (GPCRs), coupled to Gi‐type G proteins. GPR81 was discovered in 2001 and identified as the only known endogenous receptor of lactate under physiological conditions in 2008, which opened a new field of research on how lactate may act as a signal molecule along with the GPR81 expression in the roles of metabolic process and inflammatory response. Recent studies showed that the physiological functions of GPR81 include lipid metabolism in adipose tissues, metabolic excitability in the brain, cellular development, and inflammatory response modulation. These findings may reveal a novel therapeutic strategy to treat clinical, metabolic, and inflammatory diseases. This article will summarize past research on GPR81, including its characteristics of distribution and expression, functional residues, pharmacological, and physiological agonists, involvement in signal transduction, and pharmacological applications.

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Section: Erk1/2 Signaling Pathwaymentioning

confidence: 99%

The roles of GRP81 as a metabolic sensor and inflammatory mediator

Cai

Liu

et al. 2020

Journal Cellular Physiology

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“…Several investigations in last decades of the past century reported that, cyclic adenosine monophosphate (cAMP) plays an important role to influence cell growth, differentiation, proliferation and protein synthesis depending on the source of cells and experimental conditions (Bang et al, 1992; Florin-Christensen et al, 1993; Zhang et al, 2016). Takei et al (1997) found significant increase of protein production in keratinocytes subjected to cyclic strain.…”

Section: Second Messengers System In Strain-induced Responsesmentioning

confidence: 99%

Cellular and Molecular Responses to Mechanical Expansion of Tissue

et al. 2016

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The increased use of tissue expander in the past decades and its potential market values in near future give enough reasons to sum up the consequences of tissue expansion. Furthermore, the patients have the right to know underlying mechanisms of adaptation of inserted biomimetic, its bioinspired materials and probable complications. The mechanical strains during tissue expansion are related to several biological phenomena. Tissue remodeling during the expansion is highly regulated and depends on the signal transduction. Any alteration may lead to tumor formation, necrosis and/or apoptosis. In this review, stretch induced cell proliferation, apoptosis, the roles of growth factors, stretch induced ion channels, and roles of second messengers are organized. It is expected that readers from any background can understand and make a decision about tissue expansion.

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“…Mitochondria are subcellular organelles responsible for oxidative phosphorylation (OXPHOS), producing ~ 80% of the ATP in eukaryotic cells 1 , apoptosis and cell-cycle regulation 2 , redox-and calcium homeostasis 3 as well as intracellular signaling 4 . Each mitochondrion contains 2 -10 copies of a 16.6 kb double-stranded mtDNA containing 37 genes 5 .…”

Section: Introductionmentioning

confidence: 99%

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

Bybjerg‐Grauholm

Hagen

Gonçalves

et al. 2017

Preprint

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Geno-geographic affinity (ancestry background) was established with ADMIXTURE using a reference of 100K+ autosomal SNPs in 2,248 individuals from nine populations. The hg distribution was typically Northern European, and hgs were highly variable based on median-joining analysis, suggesting multiple founder events. Considerable heterogeneity and variation in autosomal genogeographic affinity was observed. Thus, individuals with hg H exhibited 95 %, and U hgs 38.2 % -92.5 %, Danish ancestry. Significant clines between geographical regions and rural and metropolitan populations were found. Over 25 years, macro-hg L increased from 0.2 % to 1.2 % (p = 1

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Mitochondrial cAMP signaling

Cited by 91 publications

References 149 publications

The roles of GRP81 as a metabolic sensor and inflammatory mediator

The roles of GRP81 as a metabolic sensor and inflammatory mediator

Cellular and Molecular Responses to Mechanical Expansion of Tissue

Complex spatio-temporal distribution and genogeographic affinity of mitochondrial DNA haplogroups in 24,216 Danes

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