Mitochondrial Biology and Parkinson's Disease

BAX channel activity mediates lysosomal disruption linked to Parkinson disease

“…[21][22][23] It was previously shown that BAX permeabilizes mitochondrial membranes in this experimental model and plays an instrumental role in MPTP-induced dopaminergic cell death. 10,11,13,21,24 Here, we assessed whether BAX may also be responsible for LMP and subsequent lysosomal deficiency occurring in this model of PD.…”

<i>Cuminum cyminum </i>Linn (Apiaceae) extract attenuates MPTP-induced oxidative stress and behavioral impairments in mouse model of Parkinson’s disease

“…MPTP damage mitochondria, proteins and lipids thereby altering the anti-oxidant enzyme status in the brain [22]. Therefore, estimating the antioxidant enzyme status in brain might be beneficial in understanding the degree of MPTPintoxication in animal models.…”

Hyperinsulinemia and Insulin Resistance: Scope of the Problem

“…Abnormalities of insulin regulation may lead to an overloading of fuel substrates into the mitochondria. The resulting oxidative stress leads to eventual mitochondrial dysfunction or destruction, which has been implicated in the pathology or progression of conditions not typically associated with IR, such as multiple sclerosis, 63,64,65 AD, 66,67 Parkinson's disease 68,69 and cancer. 44,70 Chronic hyperinsulinemia may promote systemic inflammation, 71 in part by influencing desaturase enzymes involved in the inflammatory process (via catalysing the conversion of omega-6 linoleic acid into inflammatory prostaglandins and other signalling molecules).…”