“…An increased AST/ALT ratio in patients with increased serum aminotransferase activity has also been associated with the development of cirrhosis in Nonalcoholic Steatohepatitis (Sorbi et al, 1999), even though a still higher AST/ALT ratio was observed in a group of non-biopsied patients with alcoholic liver disease. Furthermore, a high AST/ALT ratio in patients with increased serum aminotransferases has been reported in chronic viral hepatitis (Williams and Hoofnagle, 1988;Cadiot et al, 1989;Reedy et al, 1998;Sheth et al, 1998;Anderson et al, 2000;Assy and Minuk, 2000;Park et al, 2000;Giannini et al, 2001Giannini et al, , 2003Pohl et al, 2001) even though reports on relatively low positive predictive values have been published (Imperial et al, 2000).…”