Abstract:Upon oxidative stress DNA accumulates adducts and breaks that activate the genome damage response to repair, arrest and eventually suicide the damaged cell. Indeed, challenges with exogenous pro-oxidants increase mutations and reduce survival. Thus, the amounts of pro-oxidants generated by endogenous oxygen metabolism are thought to affect mutation frequency. However, oxidative stress induces cell death, clearing damaged cells.The LacZ reporter system has been used previously to detect mutation rate in flies a… Show more
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