Mitochondrial and metabolic features of salugenesis and the healing cycle

Naviaux, Robert K.

doi:10.1016/j.mito.2023.04.003

Cited by 5 publications

(4 citation statements)

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“…The biological functions of H 2 S are versatile and multidirectional, playing pivotal roles in vasodilation, neurotransmission, inflammation modulation, oxidative balance, cellular apoptosis, angiogenesis [ 35 ], glucose regulation, energy metabolism [ 36 ], and cellular survival and longevity [ 37 ]. But, all these biological functions are also part of cellular homeostasis [ 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…While previous reviews have discussed H 2 S’s involvement in vasodilation, neurotransmission, inflammation modulation, oxidative balance, apoptosis, angiogenesis, glucose regulation, energy metabolism, cellular survival, and longevity [ 35 , 36 , 37 ], our review uniquely ties these biological functions to the overarching concept of cellular homeostasis [ 38 , 39 ]. We explore further how H 2 S orchestrates multifaceted responses to maintain equilibrium within the cell, offering readers a comprehensive view of its role in various physiological processes.…”

Section: Introductionmentioning

confidence: 99%

“…We aim to delve into the current understanding of the underlying biochemical and molecular mechanisms that dictate the role of H 2 S in these processes, drawing upon the latest research from in vitro, in vivo, and clinical studies (Figure 1). While previous reviews have discussed H2S's involvement in vasodilation, neurotransmission, inflammation modulation, oxidative balance, apoptosis, angiogenesis, glucose regulation, energy metabolism, cellular survival, and longevity [35][36][37], our review uniquely ties these biological functions to the overarching concept of cellular homeostasis [38,39]. We explore further how H2S orchestrates multifaceted responses to maintain equi- While previous reviews have discussed H 2 S's involvement in vasodilation, neurotransmission, inflammation modulation, oxidative balance, apoptosis, angiogenesis, glucose regulation, energy metabolism, cellular survival, and longevity [35][36][37], our review uniquely ties these biological functions to the overarching concept of cellular homeostasis [38,39].…”

Section: Introductionmentioning

confidence: 99%

“…While previous reviews have discussed H2S's involvement in vasodilation, neurotransmission, inflammation modulation, oxidative balance, apoptosis, angiogenesis, glucose regulation, energy metabolism, cellular survival, and longevity [35][36][37], our review uniquely ties these biological functions to the overarching concept of cellular homeostasis [38,39]. We explore further how H2S orchestrates multifaceted responses to maintain equi- While previous reviews have discussed H 2 S's involvement in vasodilation, neurotransmission, inflammation modulation, oxidative balance, apoptosis, angiogenesis, glucose regulation, energy metabolism, cellular survival, and longevity [35][36][37], our review uniquely ties these biological functions to the overarching concept of cellular homeostasis [38,39]. We explore further how H 2 S orchestrates multifaceted responses to maintain equilibrium within the cell, offering readers a comprehensive view of its role in various physiological processes.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Metabolic features of treatment-refractory major depressive disorder with suicidal ideation

Pan,

Naviaux,

Wang

et al. 2023

Transl Psychiatry

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Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal ideation, and to identify individualized differences for personalized care. The study cohort consisted of 99 patients with treatment-refractory major depressive disorder and suicidal ideation (trMDD-SI n = 52 females and 47 males) and 94 age- and sex-matched healthy controls (n = 48 females and 46 males). The median age was 29 years (IQR 22–42). Targeted, broad-spectrum metabolomics measured 448 metabolites. Fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) were measured as biomarkers of mitochondrial dysfunction. The diagnostic accuracy of plasma metabolomics was over 90% (95%CI: 0.80–1.0) by area under the receiver operator characteristic (AUROC) curve analysis. Over 55% of the metabolic impact in males and 75% in females came from abnormalities in lipids. Modified purines and pyrimidines from tRNA, rRNA, and mRNA turnover were increased in the trMDD-SI group. FGF21 was increased in both males and females. Increased lactate, glutamate, and saccharopine, and decreased cystine provided evidence of reductive stress. Seventy-five percent of the metabolomic abnormalities found were individualized. Personalized deficiencies in CoQ10, flavin adenine dinucleotide (FAD), citrulline, lutein, carnitine, or folate were found. Pathways regulated by mitochondrial function dominated the metabolic signature. Peripheral blood metabolomics identified mitochondrial dysfunction and reductive stress as common denominators in suicidal ideation associated with treatment-refractory major depressive disorder. Individualized metabolic differences were found that may help with personalized management.

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Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder

Lingampelly,

Naviaux,

Heuer

et al. 2024

Commun Biol

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Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of the metabolic impact in ASD was caused by 14 shared biochemical pathways that led to decreased anti-inflammatory and antioxidant defenses, and to increased physiologic stress molecules like lactate, glycerol, cholesterol, and ceramides. CIRCOS plots and a new metabolic network parameter, $$\dot{{{\boldsymbol{V}}}}\!$$ V ° net, revealed differences in both the kind and degree of network connectivity. Of 50 biochemical pathways and 450 polar and lipid metabolites examined, the developmental regulation of the purine network was most changed. Purine network hub analysis revealed a 17-fold reversal in typically developing children. This purine network reversal did not occur in ASD. These results revealed previously unknown metabolic phenotypes, identified new developmental states of the metabolic correlation network, and underscored the role of mitochondrial functional changes, purine metabolism, and purinergic signaling in autism spectrum disorder.

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Mitochondrial and metabolic features of salugenesis and the healing cycle

Cited by 5 publications

References 266 publications

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Metabolic features of treatment-refractory major depressive disorder with suicidal ideation

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder

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