2015
DOI: 10.1371/journal.pgen.1004972
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Abstract: Reactive oxygen species (ROS) are highly reactive, oxygen-containing molecules that can cause molecular damage within the cell. While the accumulation of ROS-mediated damage is widely believed to be one of the main causes of aging, ROS also act in signaling pathways. Recent work has demonstrated that increasing levels of superoxide, one form of ROS, through treatment with paraquat, results in increased lifespan. Interestingly, treatment with paraquat robustly increases the already long lifespan of the clk-1 mi… Show more

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Cited by 170 publications
(143 citation statements)
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References 50 publications
(84 reference statements)
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“…Possibly, this complexity is needed for the optimal mobilization of cellular defense resources. Consistent with this, it has been shown earlier that in animals, mitochondrial and nonmitochondrial ROS have different effects on physiology (54).…”
Section: Discussionsupporting
confidence: 79%
“…Possibly, this complexity is needed for the optimal mobilization of cellular defense resources. Consistent with this, it has been shown earlier that in animals, mitochondrial and nonmitochondrial ROS have different effects on physiology (54).…”
Section: Discussionsupporting
confidence: 79%
“…They include mutations in clk‐1, isp‐1 , nuo‐6 , and sod‐2 which are long‐lived, as well as gas‐1 , which was originally identified as a short‐lived mutant. CLK‐1 is necessary for the biosynthesis of ubiquinone (coenzyme Q), the obligate diffusible electron carrier in the mitochondrial electron transport chain (Ewbank et al ., 1997), and clk‐1 mutants might have high mitochondrial ROS (mtROS) but low cytoplasmic ROS (Shibata et al ., 2003; Schaar et al ., 2015). ISP‐1 is the ‘Rieske’ iron sulfur protein of mitochondrial complex III (Feng et al ., 2001).…”
Section: Introductionmentioning
confidence: 99%
“…For instance, mitochondrial stress results in the activation of multiple signaling modules in addition to the UPR mt , including the hypoxia-response transcription factor HIF-1, the AMP-activated kinase pathway, and the transcription factors TAF-4 and CEH-23 (55)(56)(57). As well, increased mitochondrial ROS can activate an oxidative stress response regulated by the transcription factor SKN-1 (58). Intriguingly, ATFS-1 regulates the expression of skn-1 as part of the UPR mt transcriptional response (9).…”
Section: The Future Of the Upr Mtmentioning
confidence: 99%