Mitochondrial Acyl Carrier Protein of Leishmania major Displays Features Distinct from the Canonical Type II ACP
Chetna Dhembla,
Ambrish Kumar,
Richa Arya
et al.
Abstract:Prokaryotes synthesize fatty acids using a type II synthesis
pathway
(FAS). In this process, the central player, i.e., the acyl carrier
protein (ACP), sequesters the growing acyl chain in its internal hydrophobic
cavity. As the acyl chain length increases, the cavity expands in
size, which is reflected in the NMR chemical shift perturbations and
crystal structures of the acyl-ACP intermediates. A few eukaryotic
organelles, such as plastids and mitochondria, also harbor type II
fatty acid synthesis machinery. P… Show more
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