Mitochondrial abnormalities are involved in periodontal ligament fibroblast apoptosis induced by oxidative stress

Chen, Yuting; Ji, Yin; Jin, Xing; Sun, Xiaoyu; Zhang, Xiaorong; Chen, Yang; Shi, Lixi; Cheng, Haoran; Mao, Yixin; Li, Xumin; Hou, Yanming; Zhang, Dafeng; Zhao, Shufan; Ma, Jianfeng; Huang, Shengbin

doi:10.1016/j.bbrc.2018.12.143

Cited by 23 publications

(17 citation statements)

References 40 publications

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“…However, ROS has a very short life and is not easy to be detected. Therefore, ROS‐related destruction products and the activity of enzymatic and non‐enzymatic antioxidants are ideal candidates to evaluate the consequences of OS‐related events in the pathological process of CP (Chen et al., ).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Chen

Cai

Zhao

et al. 2019

J Clinic Periodontology

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140

118

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Aim:Oxidative stress (OS) biomarkers have been detected in saliva and gingival crevicular fluid (GCF) during chronic periodontitis (CP) progression; however, the relationship between OS biomarkers and CP progression remains elusive. The purpose of this meta-analysis is to investigate the relationship between local OS biomarkers and CP.Methods: This review was conducted through a systematic search from three databases. Studies on CP participants were included as an experimental group, and studies on periodontally healthy (PH) participants were included as a control. Mean effects were expressed as standardized mean difference with their associated 95% confidence intervals.Results: From a total of 2,972 articles, 32 articles fulfilled the inclusion criteria. We found a significant decrease of total antioxidant capacity and a significant increase of malondialdehyde (MDA), nitric oxide, total oxidant status (TOS), and 8-hydroxy-deoxyguanosine levels in the saliva of CP patients. Moreover, we also found an elevation of MDA level in GCF of CP group when compared with the PH group. There were no significant differences of salivary and GCF superoxide dismutase levels, salivary glutathione peroxidase level, and GCF TOS level between two groups. However, a high heterogeneity was observed among evaluated studies. Conclusions:Despite the limitations of this study, the result of our meta-analysis supported the rationale that there was a direct link between CP and OS-related biomarkers' levels in the local site, indicating the important role of OS in the onset and development of CP. K E Y W O R D S biomarker, chronic periodontitis, gingival crevicular fluid, oxidative stress, saliva | 609 CHEN Et al.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Chen

Cai

Zhao

et al. 2019

J Clinic Periodontology

Self Cite

140

118

View full text Add to dashboard Cite

show abstract

“…The shorter half-life and the instability of the ROS do not allow us to use them as biomarkers for periodontitis. Therefore, scientists have focused their attention on terminal products of redox reaction and antioxidant species concentration [ 78 ]. These biomarkers are researched in a fluid such as saliva and blood.…”

Section: Studies Of Possible Biomarker For Periodontitismentioning

confidence: 99%

“…8-OHdG is a biomarker of oxidative DNA damage. Chen et al [ 78 ] saw an improvement in the concentration of 8-OHdG in the saliva of the patient affected with periodontitis compared to the control group. Altingoz et al [ 93 ] conducted a study to evaluate the OS in periodontopathic patients with and without diabetes.…”

Section: Studies Of Possible Biomarker For Periodontitismentioning

confidence: 99%

The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry

Viglianisi

Tartaglia

Santonocito

et al. 2023

JPM

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Periodontitis is a multifactorial and infective oral disease that leads to the destruction of periodontal tissues and tooth loss. Although the treatment of periodontitis has improved recently, the effective treatment of periodontitis and the periodontitis-affected periodontal tissues is still a challenge. Therefore, exploring new therapeutic strategies for a personalized approach is urgent. For this reason, the aim of this study is to summarize recent advances and the potential of oxidative stress biomarkers in the early diagnosis and personalized therapeutic approaches in periodontitis. Recently, ROS metabolisms (ROMs) have been studied in the physiopathology of periodontitis. Different studies show that ROS plays a crucial role in periodontitis. In this regard, the reactive oxygen metabolites (ROMs) started to be searched for the measures of the oxidizing capacity of the plasma understood as the total content of oxygen free radicals (ROS). The oxidizing capacity of plasma is a significant indicator of the body’s oxidant state as well as homocysteine (Hcy), sulfur amino acid, which has pro-oxidant effects as it favors the production of superoxide anion. More specifically, the thioredoxin (TRX) and peroxiredoxin (PRX) systems control reactive oxygen species (ROS), such as superoxide and hydroxyl species, to transduce redox signals and change the activities of antioxidant enzymes to remove free radicals. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx), among other antioxidant enzymes, change their activity when ROS are produced in order to neutralize free radicals. The TRX system is triggered and transduces redox signals to do this.

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“…Their bond relies on peripheral blood neutrophils, which appear hyperactive in case of periodontitis and are also the main source of ROS 41 . Moreover, ROS, especially H 2 O 2 , induce the apoptosis of periodontal ligament cells, via mitochondrial abnormalities, a fact which defines oxidative stress as an independent risk factor for periodontitis 42 .…”

Section: ) Smokingmentioning

confidence: 99%

Could treating periodontitis prevent osteoporosis? An update of the last decade

Skoufou¹,

Yavropoulou²,

Zafeiris³

2019

JRPMS

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Periodontitis has often been reported as a systematic disease independently associated with a range of AbstractChronic periodontitis and osteoporosis are both systemic diseases, characterized by bone resorption. Over the last decade, their correlation has been examined closely, mainly to investigate whether they present a risk factor or an indicator for each other. It is their pathogenetic similarities, their numerous common risk factors and their frequent concomitant development that initiated researchers' interest in the precise association between these two maladies. The present review is aiming to analyse this correlation, laying emphasis on the effects of periodontal status on the skeletal bone mineral density, as suggested by the latest studies. It will also attempt to clarify whether periodontal management could influence the progression or the onset of osteoporosis.

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Mitochondrial abnormalities are involved in periodontal ligament fibroblast apoptosis induced by oxidative stress

Cited by 23 publications

References 40 publications

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

Oxidative stress‐related biomarkers in saliva and gingival crevicular fluid associated with chronic periodontitis: A systematic review and meta‐analysis

The Emerging Role of Salivary Oxidative Stress Biomarkers as Prognostic Markers of Periodontitis: New Insights for a Personalized Approach in Dentistry

Could treating periodontitis prevent osteoporosis? An update of the last decade

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