Mitochondria

Ghadially, F. N.

doi:10.1016/b978-0-407-01571-5.50010-0

Cited by 30 publications

(54 citation statements)

References 297 publications

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“…10b). 5 It is possible that loss of mitochondrial function resulted in kidney failure. This also partly explains the lipidosis observed in PT epithelial cells because mitochondria are responsible for oxidation of fatty acids.…”

Section: Discussionmentioning

confidence: 99%

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A Comprehensive Study of Easter Lily Poisoning in Cats

Rumbeiha¹,

Francis

Fitzgerald³

et al. 2004

J VET Diagn Invest

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Abstract. This study was conducted with 3 objectives in mind: first, to identify the toxic fraction (aqueous or organic) in leaves and flowers; second, to identify diagnostic marker(s) of toxicosis in cats; and, third, to evaluate the morphologic effects of intoxication. The study was conducted in 2 phases. Phase 1 was to identify which extract, organic or aqueous, was nephrotoxic and also to determine the appropriate dose for use in the phase 2 studies. Results indicated that only the aqueous extracts of leaves and flowers were nephrotoxic and pancreotoxic. To identify the proximate toxic compound, cats in the phase 2 study were orally exposed to subfractions of the aqueous flower extract, 1 subfraction per cat. Results confirmed vomiting, depression, polyuria, polydipsia, azotemia, glucosuria, proteinuria, and isosthenuria as toxic effects of the Easter lily plant. Another significant finding in serum was elevated creatinine kinase. Significant histologic kidney changes included acute necrosis of proximal convoluted tubules and degeneration of pancreatic acinar cells. Renal ultrastructural changes included swollen mitochondria, megamitochondria, edema, and lipidosis. Subfraction IIa 3 of the aqueous floral extract contained most of the toxic compound(s). These studies reproduced the clinical disease, identified the most toxic fraction of the Easter lily, and helped characterize the clinical pathology, histopathology, and ultrastructural pathology associated with the disease.

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Section: Discussionmentioning

confidence: 99%

“…Megamitochondria have been reported in a variety of tissues under diverse situations. 5 It is hypothesized that they result from fusion of individual mitochodria or through enlargement of a single mitochondrion. 5 The megamitochondria observed in PT epithelial cells are consistent with morphological descriptions in the literature (Fig.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Study of Easter Lily Poisoning in Cats

Rumbeiha¹,

Francis

Fitzgerald³

et al. 2004

J VET Diagn Invest

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“…In relatively normal cells the assumption of a cup-shaped form may augment the area of contact between mitochondrion and substrate, such as a lipid d r~p l e t ,~ but it is hard to see what this might achieve if the only organelles they can relate to are other abnormal mitochondria. 7.11.12.…”

Section: The Enigmatic Oncocytementioning

confidence: 99%

The Powerhouse of the Cell

Wills

1992

Ultrastructural Pathology

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“…5 It has been suggested that to diagnose an oncocytoma in a new location, it is mandatory to demonstrate the presence of mitochondria through electron microscopy. 8 To the best of our knowledge the diagnosis of nasal oncocytoma based on confirmatory electron micrographs has not previously been reported in the cat or any other domestic species.…”

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confidence: 99%

Nasal Oncocytoma in a Domestic Shorthair Cat

Doughty¹,

Brockman²,

Neiger³

et al. 2006

Vet Pathol

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Abstract. An oncocytoma was diagnosed in the nasal cavity of a 12-year-old Domestic Shorthair cat who presented with periocular swelling and sneezing. Histologic examination from biopsy material revealed monomorphic sheets, anastomosing cords, tubules, and acini composed of large polygonal to oval cells that contained abundant finely granular eosinophilic cytoplasm. No vascular or lymphatic invasions were noted. Histochemical stains revealed positive staining of tumor cells with periodic acidSchiff (PAS) (before and after diastase digestion) and phosphotungstic acid-hematoxylin. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for cytokeratin and negative staining for vimentin, desmin, S-100, glial fibrillar acidic protein, and neuronal specific enolase. Ultrastructurally, the tumor cells contained large numbers of mitochondria within their cytoplasm, which confirmed a diagnosis of oncocytoma.

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Mitochondria

Cited by 30 publications

References 297 publications

A Comprehensive Study of Easter Lily Poisoning in Cats

A Comprehensive Study of Easter Lily Poisoning in Cats

The Powerhouse of the Cell

Nasal Oncocytoma in a Domestic Shorthair Cat

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