Mitochondria-targeting cyclometalated iridium(III)–PEG complexes with tunable photodynamic activity

Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents

“…The phototoxic indexes of 3 against HeLa, A549 and A549R are 49, 239 and 3488, respectively. To the best of our knowledge, these are among the highest phototoxic index values ever reported for iridium complexes [41,64,65]. The result suggests that these Ir(III)eNHCs complexes may be used as potent photodynamic therapeutic agents.…”

“…1 O 2 is considered to be the main cytotoxic species in photodynamic therapy [63]. The efficiency of 1e3 to generate photosensitized 1 O 2 was determined by monitoring the dye-sensitized photooxidation of DPBF [41]. 1 O 2 quantum yields (Ф D ) were calculated using MB (Ф D ¼ 0.52) as the standard (Fig.…”

Primary reactions in the photochemistry of hexahalide complexes of platinum group metals: A minireview

“…Additionally, the photolysis products of ammonium hexachloroiridate(IV) have been reported to have anti-tumour and antimutagenic activities by Gale et al [36]. Organoiridium [37] and cyclometallated iridium complexes [33,38,39] were also proposed as prospective anticancer agents.…”

Evaluation of Perylene Bisimide‐Based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy

“…[46] Nevertheless, several Ir III compounds, most commonly bearing cyclometalated ligands, have recently been found to be promising PDT agents. [46][47][48][49][50][51][52] Figure 1. Structures of TLD-1433, a PS in clinical trial as a PDT PS, and complexes 1 and 2 with their respective ligands L1 and L2 studied in this paper.…”