Mitochondria-targeted carbon monoxide delivery combined with singlet oxygen production from a single nanoplatform under 808 nm light irradiation for synergistic anticancer therapy

Abstract

A multifunctional nanoplatform, MnCO@TPP@C-TiO2, which consists of a carrier of carbon-doped TiO2 nanoparticles with surface covalent functionalization of manganese carbonyls and a directing group of triphenylphosphine, was prepared for mitochondria-targeted...

Targeted carbon monoxide delivery combined with chemodynamic, chemotherapeutic and photothermal therapies for enhanced antitumor efficacy

“…Release of CO from HDPMF was evaluated using both a fluorescent probe (FL-CO-1 + PdCl 2 ) and a hemoglobin (Hb) assay. 33 In the presence of the probe, when the HDPMF solution was irradiated by 808 nm NIR light, the fluorescence intensity of the probe at 513 nm increased gradually (Fig. 2B), suggesting NIR light triggered CO release from HDPMF.…”

“…Procedures for intracellular ROS detection were the same as our previous report. 33 HeLa cells were incubated with HDPMF (15 mg mL À1 ) for 4 h, and were then washed thrice with PBS buffer, followed by incubation with DCFH-DA (10 mM) for 20 min. Finally, cells were washed thrice with PBS buffer and irradiated with an 808 nm laser (1.0 W cm À2 , 10 min) prior to imaging.…”

A mitochondria-localized iridium(iii)–chlorin E6 conjugate for synergistic sonodynamic and two-photon photodynamic therapy against melanoma

“…Mitochondria are one of the most promising targets due to their sensitivity to ROS and the effective induction of programmed forms of cell death by redox inbalances. 43,44 Fortunately, the vast majority of cyclometalated iridium(III) complexes have been found to be promising mitochondria targeting agents, probably attributed to their lipophilic and cationic nature. 12,13,45 Based on these previous studies, chlorin e6 (Ce6) was conjugated to a cyclometalated iridium(III) complex to form the novel sono-photosensitizer conjugate IrCe6 for synergistic SDT and two-photon PDT against melanoma (Scheme 1).…”

“…Mitochondria are one of the most promising targets due to their sensitivity to ROS and the effective induction of programmed forms of cell death by redox inbalances. 43,44 Fortunately, the vast majority of cyclometalated iridium( iii ) complexes have been found to be promising mitochondria targeting agents, probably attributed to their lipophilic and cationic nature. 12,13,45…”

A multifunctional nanoplatform delivering carbon monoxide and a cysteine protease inhibitor to mitochondria under NIR light shows enhanced synergistic anticancer efficacy

“…22 The primary target of CO is the mitochondria of cancer cells, where it accelerates cellular respiration and leads to O 2 depletion and overproduction of reactive oxygen species, thus damaging mitochondria, depleting ATP, and producing other pro-apoptotic effects. 23,24 In addition, CO can traverse freely in various biofilms and tumor stroma, 25 it has great potential to complement photodynamic therapy (PDT), [26][27][28][29] sonodynamic therapy (SDT), 30 chemodynamic therapy (CDT), [31][32][33] chemotherapy, 34 and photothermal therapy (PTT). 35,36 Integrating the therapeutic CO gas with an enzyme inhibitor may provide additional beneficial effects of CO to the anticancer efficiency of the enzyme inhibitor and thus achieving high therapeutic efficacy.…”