Mitochondria-Targeted Antioxidant Therapeutics for Traumatic Brain Injury
Hiren R. Modi,
Sudeep Musyaju,
Meaghan Ratcliffe
et al.
Abstract:Traumatic brain injury (TBI) is a major global health problem that affects both civilian and military populations worldwide. Post-injury acute, sub-acute, and chronic progression of secondary injury processes may contribute further to other neurodegenerative diseases. However, there are no approved therapeutic options available that can attenuate TBI-related progressive pathophysiology. Recent advances in preclinical research have identified that mitochondria-centric redox imbalance, bioenergetics failure and … Show more
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