Abstract:Neurons are highly dependent on mitochondrial function, and mitochondrial damage has been implicated in many neurological and neurodegenerative diseases. Relatively little is known about how mitochondria regulate neuronal function. Here we show that axonal mitochondria are necessary for neuropeptide secretion in Caenorhabditis elegans, and that oxidative phosphorylation, but not mitochondrial calcium uptake, is required for secretion. Oxidative phosphorylation produces cellular ATP, reactive oxygen species, an… Show more
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