Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications

Abstract

Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be closely associated with the development of many diseases. Mitochondria are vital components of eukaryotic cells, serving important functions in energy production, cellular metabolism, and apoptosis regulation. Presently, the precise relationship between mitochondria and ferroptosis remains unclear. In this study, we aim to systematically elucidate the mechanisms via which mitochondria regulate ferroptosis from multiple perspectives to provide novel insights into mitochondrial functions in ferroptosis. Additionally, we present a comprehensive overview of how mitochondria contribute to ferroptosis in different conditions, including cancer, cardiovascular disease, inflammatory disease, mitochondrial DNA depletion syndrome, and novel coronavirus pneumonia. Gaining a comprehensive understanding of the involvement of mitochondria in ferroptosis could lead to more effective approaches for both basic cell biology studies and medical treatments.

Evidence based on Mendelian randomization: Causal relationship between mitochondrial biological function and lung cancer and its subtypes

“…Contemporary research underscores the connection between mitochondria and lung cancer, thereby establishing it as a pivotal factor influencing the initiation and progression of lung cancer. Inhibition of mitochondrial function has demonstrated the potential to impede the onset and proliferation of lung cancer [ 23 , 24 ].…”

A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencing

“…In our study, we constructed a novel 4-gene risk model associated with disulfidptosis based on a combination of the DRGs and scRNA sequencing data of papillary thyroid carcinoma. As a newly discovered type of programmed cell death, disulfidptosis is considered to be closely related to the occurrence and development of tumors as ferroptosis and cuproptosis death which were fully explored in the past ( Feng et al, 2023 ; Hadian and Stockwell, 2023 ; Zhang et al, 2023 ). In-depth exploration of these cell death processes will help us to deepen our understanding of the mechanisms behind tumor development and provide evidence for investigating new treatments.…”

Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions

“…Additionally, it differs from other regulated cell deaths in terms of its morphology and underlying mechanisms. Diverse processes, including iron, energy, lipid metabolisms, and specific small molecules, influence the course of ferroptosis and the susceptibility of cells to the process ( Feng et al, 2023 ). Given the emerging understanding of ferroptosis, it has been implicated in the pathogenesis of malaria.…”