Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

Cisneros, Jasmine; Belton, Tayler B.; Shum, George C.; Molakal, Catherine G.; Wong, Yvette C.

doi:10.1016/j.tins.2022.01.005

Cited by 56 publications

(47 citation statements)

References 69 publications

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“…The possibility to follow this dynamic interaction at high spatio-temporal resolution should help to clarify its role in multiple human pathologies. 18 xHTLs also allowed the live-cell 3D STED imaging of the mitochondrial surface (TOM20-dHaloTag7) and matrix (Cox8A-HaloTag7), respectively labeled with SiR-HSAm and CRh-Hy4, in a volume of 15.6 μm 3 (50 nm z-stacks, Fig. 2I ).…”

Section: Mainmentioning

confidence: 99%

Exchangeable HaloTag Ligands (xHTLs) for multi-modal super-resolution fluorescence microscopy

Kompa

Bruins

Glogger

et al. 2022

Preprint

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We introduce exchangeable ligands for fluorescence labeling of HaloTag7 as an alternative to covalently bound probes. The exchangeable ligands open up new possibilities in imaging for a widely used labeling approach, including applications in points accumulation for imaging in nanoscale topography (PAINT), MINFLUX and live-cell, multi-frame stimulated emission depletion (STED) microscopy. We furthermore introduce orthogonal pairs of exchangeable ligands and HaloTags for dual-color PAINT and STED microscopy.

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Section: Mainmentioning

confidence: 99%

Exchangeable HaloTag Ligands (xHTLs) for multi-modal super-resolution fluorescence microscopy

Kompa

Bruins

Glogger

et al. 2022

Preprint

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“…Genetic and functional evidence indicate that the crosstalk between lysosomes and mitochondria is critically disturbed in PD, ranging from mitophagy and mitochondrial-derived vesicles to contact sites. While this was already the topic of other excellent reviews (Bai et al, 2020;Deus et al, 2020;Ray et al, 2021;Cisneros et al, 2022), we here focus on mito-LE/Lys MCSs in light of new recent findings and possible connections to other contact sites.…”

Section: Mitochondria-late Endosome/lysosome Contacts Parkinson's Dis...mentioning

confidence: 99%

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites

et al. 2022

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Neurodegenerative diseases (NDs) are generally considered proteinopathies but whereas this may initiate disease in familial cases, onset in sporadic diseases may originate from a gradually disrupted organellar homeostasis. Herein, endolysosomal abnormalities, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and altered lipid metabolism are commonly observed in early preclinical stages of major NDs, including Parkinson's disease (PD) and Alzheimer's disease (AD). Among the multitude of underlying defective molecular mechanisms that have been suggested in the past decades, dysregulation of inter-organellar communication through the so-called membrane contact sites (MCSs) is becoming increasingly apparent. Although MCSs exist between almost every other type of subcellular organelle, to date, most focus has been put on defective communication between the ER and mitochondria in NDs, given these compartments are critical in neuronal survival. Contributions of other MCSs, notably those with endolysosomes and lipid droplets are emerging, supported as well by genetic studies, identifying genes functionally involved in lysosomal homeostasis. In this review, we summarize the molecular identity of the organelle interactome in yeast and mammalian cells, and critically evaluate the evidence supporting the contribution of disturbed MCSs to the general disrupted inter-organellar homeostasis in NDs, taking PD and AD as major examples.

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“…Furthermore, the authors reported that [ 64 Cu]Cu-ATSM-FITC had higher uptake in lipopolysaccharide-induced neuroinflammation models. The preclinical promise can potentially be translated into clinical reality to detect brain diseases [80][81][82][83]. Initial studies have shown the diffuse uptake of [ 62 Cu]Cu-ATSM in healthy controls and neurological diseases [54,55].…”

Section: Cu]cu-atsm-fitc Is An Emerging Agent Sensing Hydrogen Sulfidementioning

confidence: 99%

[64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation

Xie

Wei

2022

Eur J Nucl Med Mol Imaging

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Mitochondria-lysosome contact site dynamics and misregulation in neurodegenerative diseases

Cited by 56 publications

References 69 publications

Exchangeable HaloTag Ligands (xHTLs) for multi-modal super-resolution fluorescence microscopy

Exchangeable HaloTag Ligands (xHTLs) for multi-modal super-resolution fluorescence microscopy

Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites

[64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation

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