Mitochondria in Health and Diseases

Javadov, Sabzali; Kozlov, Andrey V.; Camara, Amadou K.S.

doi:10.3390/cells9051177

Cited by 128 publications

(78 citation statements)

References 27 publications

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“…It is, however, possible that the domain(s) regulating LETM1-CHE/KHE would influence the interaction of LETM1 with proteins such as BCS1L and hence the regulation of mitochondrial morphology and vice versa. Given the increasing importance of inter-organelle communications and signaling for integrated cellular function in health and disease ( Javadov et al, 2020 ), this aspect of LETM1-mediated signaling, in addition to its exchanger function needs further investigation.…”

Section: Perspectivementioning

confidence: 99%

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

et al. 2021

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Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.

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Section: Perspectivementioning

confidence: 99%

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

et al. 2021

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“…Previous age-related research has identified several cellular pathways that are consistently found to be dysregulated during ageing and in age-related disease. Cell energy and metabolism, including mitochondrial dysfunction, is one of the top processes (31)(32)(33). Proteins such as clusterin, superoxide dismutase 1(SOD1), and apolipoprotein E have previously been found to be dysregulated in ageing (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

“…In trabecular bone we observed decline in several collagens and proteoglycans, which are major structural components of the ECM. Bone also displayed a very strong metabolic, mitochondrial signature that has been linked to many ageing processes (32,33).…”

Section: Discussionmentioning

confidence: 99%

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

Ariosa-Morejon

Santos

Fisher

et al. 2021

Preprint

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Collagen-rich tissues have poor reparative capacity that is further impaired with age, predisposing to common age-related disorders such as osteoporosis and osteoarthritis. We used in vivo pulsed SILAC labelling to quantify new protein incorporation into cartilage, bone, skin and plasma of mice across the life course. We report highly dynamic matrisome turnover in bone and cartilage during skeletal maturation, which was markedly reduced after skeletal maturity. Comparing young adult with older adult mice, new protein incorporation was reduced in all tissues. STRING clustering revealed epigenetic modulation across all tissues, a decline in chondroprotective growth factors such as FGF2 and TGFb in cartilage, and clusters indicating mitochondrial dysregulation and reduced collagen synthesis in bone. Several of these pathways have been associated with age-related disease. Fewer changes were observed for skin and plasma. This methodology provides dynamic protein data at a tissue level, uncovering age-related molecular changes that may predispose to disease.

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“…Mitochondria are small subcellular organelles that generate adenosine triphosphate (ATP) to power various cell functions in all eukaryotic cells [ 1 , 2 , 3 , 4 ]. Mitochondria also control homeostasis and redox signaling and regulate cell apoptosis and death [ 1 , 2 , 3 , 4 ]. An alkaline pH ≈ 8.0 is essential in mitochondria to sustain the proton motive potential during the synthesis of ATP [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Ratiometric Near-Infrared Fluorescent Probes Based on Hemicyanine Dyes Bearing Dithioacetal and Formal Residues for pH Detection in Mitochondria

et al. 2021

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Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses to pH changes through the protonation and deprotonaton of a hydroxy group in hemicyanine dyes with experimentally determined pKa values of 6.85 and 6.49, respectively. Calculated pKa values from a variety of theoretical methods indicated that the SMDBONDI method of accounting for solvent and van der Waals radii plus including a water molecule located near the site of protonation produced the closest overall agreement with the experimental values at 7.33 and 6.14 for AH+ and BH+ respectively.

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Mitochondria in Health and Diseases

Cited by 128 publications

References 27 publications

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling

Age-dependent changes in protein incorporation into collagen-rich tissues of mice by in vivo pulsed SILAC labelling

Ratiometric Near-Infrared Fluorescent Probes Based on Hemicyanine Dyes Bearing Dithioacetal and Formal Residues for pH Detection in Mitochondria

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