“…On the basis of these observations, we support that MFN2 plays a key role in restoring mitochondrial function in HG-induced HLE-B3 cells. In addition, mitochondria and endoplasmic reticulum (ER) are distinct organelles that physically interact with each other, including exchange of phospholipids, calcium and other metabolites to maintain cellular integrity and bioenergetics [31][32][33]. Previous studies have reported that MFN2 promotes the contact of mitochondria and ER [32,34,35].…”