Mitochondria as Chi

Wallace, Douglas C.

doi:10.1534/genetics.104.91769

Cited by 137 publications

(130 citation statements)

References 97 publications

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“…This choice is made cell by cell early in embryogenesis and is mitotically remembered in cell lineages thereafter, creating somatic mosaics within and thus phenotypic variation among nominally identical heterozygotes at the locus. Even the humble mitochondria have surprising proliferating effects that can be somatic as well as inherited (Wallace 2008). Somatic changes, including mutations, contribute phenogenetic variation that is not transmitted across generations and hence is cryptic to mapping strategies (Weiss 2005).…”

Section: Much Ado About Too Little?mentioning

confidence: 99%

Tilting at Quixotic Trait Loci (QTL): An Evolutionary Perspective on Genetic Causation

Weiss

2008

Genetics

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Recent years have seen great advances in generating and analyzing data to identify the genetic architecture of biological traits. Human disease has understandably received intense research focus, and the genes responsible for most Mendelian diseases have successfully been identified. However, the same advances have shown a consistent if less satisfying pattern, in which complex traits are affected by variation in large numbers of genes, most of which have individually minor or statistically elusive effects, leaving the bulk of genetic etiology unaccounted for. This pattern applies to diverse and unrelated traits, not just disease, in basically all species, and is consistent with evolutionary expectations, raising challenging questions about the best way to approach and understand biological complexity.

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Section: Much Ado About Too Little?mentioning

confidence: 99%

Tilting at Quixotic Trait Loci (QTL): An Evolutionary Perspective on Genetic Causation

Weiss

2008

Genetics

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“…ROS have been associated with diverse cellular processes such as apoptosis, metastasis, and signal transduction for cell proliferation [1,2]. These processes demonstrate that mitochondria are essential for maintaining the health of an organism [3].…”

Section: Introductionmentioning

confidence: 99%

Part II. Mitochondrial mutational status of high nitric oxide adapted cell line BT-20 (BT-20-HNO) as it relates to human primary breast tumors

et al. 2012

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“…Population-specific mtDNA polymorphisms have been linked to predisposition to a broad range of metabolic and degenerative diseases (3,10,11). These variants are generally ancient, having accumulated along radiating maternal lineages during the human expansion out of Africa.…”

mentioning

confidence: 99%