Mitochondria-anchoring and AIE-active photosensitizer for self-monitored cholangiocarcinoma therapy

Zhou, Tao; Zhu, Jingjing; Shang, Dan; Chai, Chuxing; Li, Youzhen; Sun, Haiying; Li, Yongqin; Gao, Meng; Li, Min

doi:10.1039/d0qm00503g

Cited by 20 publications

(14 citation statements)

References 41 publications

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“…Additionally, cationic pyridinium and triphenylphosphonium moieties have been reported to be capable of targeting mitochondria. 15,[43][44][45][46][47][48][49][50] Therefore, in the target molecule, we introduced an ynone group to act as the covalent binding with amines on mitochondria and selected the cationic pyridinium moiety to achieve the targeting of mitochondria. According to our knowledge, such a unique AIE probe that combines both mitochondrial targeting and in situ nontoxic, high-efficiency bioconjugation functions has not been reported to date.…”

Section: Design Strategy Synthesis and Photophysical Propertiesmentioning

confidence: 99%

“…42 Meanwhile, we selected a cationic pyridinium moiety to achieve the targeting of mitochondria. 12,[43][44][45] The resulting AIEgen, TPAP-C5-yne (Figure 1), successfully achieved the precise and up to 7-days tracking of mitochondria and the visualization of the motion of a single mitochondrion in live primary rat hippocampal neurons, which has not been reported to date.…”

Section: Introductionmentioning

confidence: 99%

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Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Park

Niu

et al. 2022

Chem. Sci.

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Section: Design Strategy Synthesis and Photophysical Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Park

Niu

et al. 2022

Chem. Sci.

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“…Mitochondria in tumor cells are sensitive to ROS generation induced by PDT, which ultimately induces tumor cell apoptosis by disrupting the balance of mitochondrial ROS [36]. Recently, several AIEgens have been designed for targeting mitochondria and have exhibited remarkable photostability, high brightness, and excellent PDT effect [37][38][39][40]. However, multiple doses and repeated injections of PSs are always required for better outcomes in PDT procedures, which may lead to superfluous side effects and additional toxicity to patients [36].…”

Section: Introductionmentioning

confidence: 99%

Multiple Light-Activated Photodynamic Therapy of Tetraphenylethylene Derivative with AIE Characteristics for Hepatocellular Carcinoma via Dual-Organelles Targeting

et al. 2022

Self Cite

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Photodynamic therapy (PDT) has emerged as a promising locoregional therapy of hepatocellular carcinoma (HCC). The utilization of luminogens with aggregation-induced emission (AIE) characteristics provides a new opportunity to design functional photosensitizers (PS). PSs targeting the critical organelles that are susceptible to reactive oxygen species damage is a promising strategy to enhance the effectiveness of PDT. In this paper, a new PS, 1-[2-hydroxyethyl]-4-[4-(1,2,2-triphenylvinyl)styryl]pyridinium bromide (TPE-Py-OH) of tetraphenylethylene derivative with AIE feature was designed and synthesized for PDT. The TPE-Py-OH can not only simultaneously target lipid droplets and mitochondria, but also stay in cells for a long period (more than 7 days). Taking advantage of the long retention ability of TPE-Py-OH in tumor, the PDT effect of TPE-Py-OH can be activated through multiple irradiations after one injection, which provides a specific multiple light-activated PDT effect. We believe that this AIE-active PS will be promising for the tracking and photodynamic ablation of HCC with sustained effectiveness.

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“…More importantly, it is the first time to explore the ultrastructural changes in mitochondrial morphology caused by AIE‐based PDT, which is conducive to understanding the mechanism. [ 60 ]…”

Section: Boosted Aiegen‐based Pdtmentioning

confidence: 99%

Recent Advances in AIEgen‐Based Photodynamic Therapy and Immunotherapy

Zha

Yang

et al. 2021

Adv Healthcare Materials

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Cancer, one of the leading causes of death, has seriously threatened public health. However, there is still a lack of effective treatments. Nowadays, photodynamic therapy (PDT), relying on photosensitizers to trigger the generation of reactive oxygen species (ROS) for killing cancer cells, has been emerging as a noninvasive anti‐cancer strategy. To enhance the overall anti‐cancer efficacy of PDT, various approaches including molecular design and combination with other therapeutic techniques have been proposed and implemented. Especially, photodynamic immunotherapy that can effectively evoke the body's immune response has attracted much attention. Recently, a class of photosensitizers with aggregation‐induced emission (AIE) character have shown unique promises, taking advantage of their profound fluorescence and ROS‐generating ability in the aggregation state. Despite the promising results demonstrated by several groups, the associated studies are few and the mechanism of such AIEgen‐based photodynamic immunotherapy has not been fully understood. This review discusses the recent advances in the AIEgen‐based enhanced PDT with a special focus on the AIE photosensitizers for photodynamic immunotherapy, aiming to inspire more opportunities for in‐depth investigation of the working principles in this emerging anti‐cancer approach.

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Mitochondria-anchoring and AIE-active photosensitizer for self-monitored cholangiocarcinoma therapy

Abstract: The morbidity of extrahepatic cholangiocarcinoma (CCA) increased markedly in the past few decades. However, most of patients with extrahepatic CCA are diagnosed at an advanced stage and can’t receive curative...

Cited by 20 publications

References 41 publications

Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen

Multiple Light-Activated Photodynamic Therapy of Tetraphenylethylene Derivative with AIE Characteristics for Hepatocellular Carcinoma via Dual-Organelles Targeting

Recent Advances in AIEgen‐Based Photodynamic Therapy and Immunotherapy

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