Mitigation of nonalcoholic fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

Khoo, Weslie; Chrisfield, Benjamin J.; Sae-tan, Sudathip; Lambert, Joshua D.

doi:10.1016/j.jnutbio.2019.108262

Cited by 18 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in teas, and it could effectively regulate energy metabolism, lipid oxidation, and insulin resistance [ 65 , 66 ]. Thus, tea polyphenols could be considered a potential adjuvant therapy to modulate metabolic syndromes in FLD patients [ 67 , 68 ].…”

Section: Beneficial Bioactive Compounds From Plant-based Foods In mentioning

confidence: 99%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Fatty liver disease (FLD), including nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), is a serious chronic metabolic disease that affects a wide range of people. Lipid accumulation accompanied by oxidative stress and inflammation in the liver is the most important pathogenesis of FLD. The plant-based, high-fiber, and low-fat diet has been recommended to manage FLD for a long time. This review discusses the current state of the art into the effects, mechanisms, and clinical application of plant-based foods in NAFLD and AFLD, with highlighting related molecular mechanisms. Epidemiological evidence revealed that the consumption of several plant-based foods was beneficial to alleviating FLD. Further experimental studies found out that fruits, spices, teas, coffee, and other plants, as well as their bioactive compounds, such as resveratrol, anthocyanin, curcumin, and tea polyphenols, could alleviate FLD by ameliorating hepatic steatosis, oxidative stress, inflammation, gut dysbiosis, and apoptosis, as well as regulating autophagy and ethanol metabolism. More importantly, clinical trials confirmed the beneficial effects of plant-based foods on patients with fatty liver. However, several issues need to be further studied especially the safety and effective doses of plant-based foods and their bioactive compounds. Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

show abstract

Section: Beneficial Bioactive Compounds From Plant-based Foods In mentioning

confidence: 99%

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Gan

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…98 Furthermore, green tea reduced the activity of the nuclear factor-kappa β, which is involved in the development of liver inflammation. 99 Even white tea showed excellent potential in preventing liver damage due to its antioxidant effects. 25,100 According to Sanlier et al, both EGCG and white tea extract limited the oxidative damage of hepatocytes and red blood cells caused by Benzo (a) pyrene.…”

Section: Effect On the Liver Systemmentioning

confidence: 99%

“…This effect was observed in subjects with hepatic damage, whereas for healthy individuals a detrimental effect was observed. 99 Given the variability of the results and the possible toxic effects, further studies are necessary.…”

Section: Effect On the Liver Systemmentioning

confidence: 99%

Green and white teas as health-promoting foods

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Lifestyle interventions, including Ex, dietary, and behavior modification, may work together to achieve the hepatoprotective effect ( 29 ). Food rich in polyphenols, like green tea, combined with voluntary Ex could produce a more efficient effect on mitigating NAFLD than Ex alone ( 30 ). Consistent with this, the present study demonstrated that less hepatic TG concentration was found in the Ex-FA group compared to that in the Ex group ( Table 1 ), which implied that the synergetic action of FA and Ex exerted a more outstanding benefit on liver protection.…”

Section: Discussionmentioning

confidence: 99%

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

et al. 2022

View full text Add to dashboard Cite

Exercise (Ex) has been recognized as an effective way of obesity prevention, but it shows a dual effect on the body's antioxidant system. Ferulic acid (FA) is a kind of phenolic acid with well-known antioxidant capacity and numerous health benefits. Therefore, the aim of the study was to compare the antiobesity effect of Ex, FA, and Ex combined with FA (Ex-FA) in vivo and to illustrate the potential mechanisms. Mice were fed a high-fat diet (HFD) with or without administration of Ex, FA, and Ex-FA for 13 weeks. The body weight, antioxidant ability, Ex performance, and lipid profiles in the serum, liver, and skeletal muscle were compared among the groups, and serum metabolomics analysis was conducted. The results showed that Ex, FA, and Ex-FA exhibited a similar effect on body weight management. Ex had a more beneficial function by alleviating HFD-induced dyslipidemia than FA, while FA exerted a more efficient effect in mitigating lipid deposition in the liver and skeletal muscle. Ex-FA showed comprehensive effects in the regulation of the lipid contents in serum, liver, and skeletal muscle, and provoked enhancement effects on antioxidant ability and Ex capacity. Mice administered with Ex, FA, and Ex-FA showed different metabolic profiles, which might be achieved through different metabolic pathways. The findings of this research implied that Ex coupled with FA could become an effective and safe remedy for the management of dietary-induced obesity.

show abstract

Mitigation of nonalcoholic fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise

Cited by 18 publications

References 45 publications

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Green and white teas as health-promoting foods

Regular exercise combined with ferulic acid exhibits antiobesity effect and regulates metabolic profiles in high-fat diet-induced mice

Contact Info

Product

Resources

About