Mitigation of chronic unpredictable stress–induced cognitive deficits in mice by &lt;i&gt;Lycium barbarum&lt;/i&gt; L (Solanaceae) polysaccharides

Xue, Min-Qiu; Quan, Hongfeng; Wang, Rui; Zhao, Xiaolu; Lin, Yi; Zhu, Yu; Jing, Jing; Bing, Hua; Peng, Xiao-Dong

doi:10.4314/tjpr.v16i8.20

Cited by 6 publications

(4 citation statements)

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“…A recent study indicated that pretreatment of the human retinal epithelial cell line (ARPE- 19) with LBPs showed that LBPs are highly efficient in reducing oxidative damage and inhibiting cell apoptosis. Furthermore, LBPs may regulate the expression of proteins involved in the apoptotic pathway and activate the Nrf2 signaling pathway [20].…”

Section: Antioxidative Damage Function and Molecular Mechanism Of Lbp...mentioning

confidence: 99%

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Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Han¹,

Wang²,

Mo³

et al. 2021

Brain Science Advances

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Lycium barbarum polysaccharides (LBPs) are the major polysaccharides extracted from L. barbarum, which is used in traditional Chinese medicine (TCM) for treating diseases. Studies have shown that LBPs have important biological activities, such as antioxidation, anti-aging, neuroprotection, immune regulation. LBPs inhibit oxidative stress, improve neurodegeneration and stroke-induced neural injury, increase proliferation and differentiation of neural stem cell, and promote neural regeneration. Here we have reviewed latest advances in the biomedical activities of LBPs and improved methods for the isolation, extraction, and purification of LBPs. Then, new discoveries to decrease oxidative stress and cellular apoptosis, inhibit aging progress, and improve neural repair in neurodegeneration and ischemic brain injury have been discussed in detail through in vitro cell culture and in vivo animal studies. Importantly, the molecular mechanisms of LBPs in playing neuroprotective roles are further explored. Lastly, we discuss the perspective of LBPs as biomedical compounds in TCM and modern medicine and provide the experimental and theoretical evidence to use LBPs for the treatment of aging-related neurological diseases and stroke-induced neural injuries.

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Section: Antioxidative Damage Function and Molecular Mechanism Of Lbp...mentioning

confidence: 99%

“…SOD plays an important role in maintaining the dynamic balance of ROS. Studies have shown that the exogenous supplementation of LBPs significantly increased SOD activity in the retina after 3 months [18, 19].…”

Section: Antioxidative Damage Function and Molecular Mechanism Of Lbp...mentioning

confidence: 99%

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Han¹,

Wang²,

Mo³

et al. 2021

Brain Science Advances

View full text Add to dashboard Cite

show abstract

“…Neuronal damage occurs in the hippocampus under chronic stress (Bakhtiarzadeh et al, 2018;Surget et al, 2011;Xue et al, 2017). The number of neurons in CA1 and CA3 of the hippocampus was counted in the Nissl stained sections.…”

Section: Honey Supplementation Ameliorated the Neuronal Loss In The Hippocampus Induced By Cumsmentioning

confidence: 99%

“…It has been reported that chronic unpredictable mild stress (CUMS) induces learning and memory impairment and also depression (Liu et al, 2014;Willner, 2017;Wu et al, 2017). Meanwhile, It has been shown that CUMS induces a neuronal loss in the hippocampus (Bakhtiarzadeh et al, 2018;Surget et al, 2011;Xue et al, 2017). In the current study, we tried to evaluate the effect of Iranian honey on learning and memory impairment as well as depression, which were induced by CUMS.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of honey on learning and memory impairment, depression and neurodegeneration induced by chronic unpredictable mild stress

2020

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Introduction: Chronic stress, which has been prevalent in human life, induce structural changes in the hippocampus. Depression and impairment of memory are serious comorbidities of chronic stress. In this study, we evaluated the impact of an Iranian honey pretreatment on memory deficit, depression and the hippocampal neuronal loss in the chronic unpredictable mild stress (CUMS) model. Methods: Adult male Wistar rats were divided into the control groups that received water or honey (0.2 or 2g/kg) and CUMS groups that subjected different, randomly and unpredictable mild stressors for 4 weeks. Ten days before starting the CUMS procedures, the animals received honey (0.2 or 2g/kg, daily, orally), which was continued until sacrificing. Morris water maze and sucrose performance tests were used to evaluate the spatial learning and memory and depressive-like behavior in the animals respectively. Hippocampus and whole brain samples were collected for further biochemical and histological analysis. Results: Honey reversed the depression-like behavior and ameliorated the spatial memory deficit induced by CUMS. Also, honey decreased cell death in the hippocampus and reduced the malondialdehyde level in treated animals. Conclusion: These results revealed that honey diminished learning and memory deficits and depression in chronic stress conditions.

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Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: A comprehensive review

Rang

Liu

2022

International Journal of Biological Macromolecules

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Mitigation of chronic unpredictable stress–induced cognitive deficits in mice by <i>Lycium barbarum</i> L (Solanaceae) polysaccharides

Cited by 6 publications

References 20 publications

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Research advances on antioxidation, neuroprotection, and molecular mechanisms of Lycium barbarum polysaccharides

Protective effect of honey on learning and memory impairment, depression and neurodegeneration induced by chronic unpredictable mild stress

Potential for non-starch polysaccharides in the prevention and remediation of cognitive impairment: A comprehensive review

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