Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome

Pakdeechote, Poungrat; Poasakate, Anuson; Prasatthong, Patoomporn; Potue, Prapassorn; Khamseekaew, Juthamas; Maneesai, Putcharawipa

doi:10.1016/j.heliyon.2023.e16500

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…In nature, it can be found particularly concentrated in propolis and in Alpinia officinarum, a plant commonly known as galanga, after which it has been named. It shows pleiotropic bioactivities, having been demonstrated that is not only able to inhibit oxidative stress and inflammation but also exert antifibrotic, antimicrobial, and antihypertensive effects and even reduce vascular abnormalities in rat models of metabolic syndrome [116,117]. For some of these properties, its possible application in cancer was hypothesized, as well as in a series of inflammatory and degenerative diseases, including skin diseases, rheumatoid arthritis, osteoarthritis, neurodegenerative diseases, and osteoporosis [116,[118][119][120].…”

Section: Flavonoids and Dox-induced Chemobrainmentioning

confidence: 99%

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

Serini,

Calviello

2024

Antioxidants

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Chemotherapy-induced cognitive impairment or “chemobrain” is a prevalent long-term complication of chemotherapy and one of the more devastating. Most of the studies performed so far to identify the cognitive dysfunctions induced by antineoplastic chemotherapies have been focused on treatment with anthracyclines, frequently administered to breast cancer patients, a population that, after treatment, shows a high possibility of long survival and, consequently, of chemobrain development. In the last few years, different possible strategies have been explored to prevent or reduce chemobrain induced by the anthracycline doxorubicin (DOX), known to promote oxidative stress and inflammation, which have been strongly implicated in the development of this brain dysfunction. Here, we have critically analyzed the results of the preclinical studies from the last few years that have evaluated the potential of phenolic compounds (PheCs), a large class of natural products able to exert powerful antioxidant and anti-inflammatory activities, in inhibiting DOX-induced chemobrain. Several PheCs belonging to different classes have been shown to be able to revert DOX-induced brain morphological damages and deficits associated with learning, memory, and exploratory behavior. We have analyzed the biological and molecular mechanisms implicated and suggested possible future perspectives in this research area.

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Section: Flavonoids and Dox-induced Chemobrainmentioning

confidence: 99%

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

Serini,

Calviello

2024

Antioxidants

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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Niu,

Feng,

Peng

et al. 2024

Phytotherapy Research

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Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, with mechanisms related to peroxisome proliferator‐activated receptors, nuclear factor kappa‐B, AMP‐activated protein kinase, nuclear factor (erythroid‐derived 2)‐like 2, glucose transporter type 4, and phosphatidylinositol‐3‐kinase/protein kinase B pathway. However, a comprehensive summary of the flavonoid effects on GLMD is lacking. This study reviewed the roles and mechanisms of natural flavonoids with different structures in the treatment of GLMD reported globally in the past 5 years and provides a reference for developing flavonoids as drugs for treating GLMD.

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Galangin: A Promising Flavonoid for the Treatment of Rheumatoid Arthritis—Mechanisms, Evidence, and Therapeutic Potential

Khawaja,

El-Orfali,

Shoujaa

et al. 2024

Pharmaceuticals

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Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation and damage. Oxidative stress plays a critical role in the onset and progression of RA, significantly contributing to the disease’s symptoms. The complex nature of RA and the role of oxidative stress make it particularly challenging to treat effectively. This article presents a comprehensive review of RA’s development, progression, and the emergence of novel treatments, introducing Galangin (GAL), a natural flavonoid compound sourced from various plants, as a promising candidate. The bioactive properties of GAL, including its anti-inflammatory, antioxidant, and immunomodulatory effects, are discussed in detail. The review elucidates GAL’s mechanisms of action, focusing on its interactions with key targets such as inflammatory cytokines (e.g., TNF-α, IL-6), enzymes (e.g., SOD, MMPs), and signaling pathways (e.g., NF-κB, MAPK), which impact inflammatory responses, immune cell activation, and joint damage. The review also addresses the lack of comprehensive understanding of potential treatment options for RA, particularly in relation to the role of GAL as a therapeutic candidate. It highlights the need for further research and clinical studies to ascertain the effectiveness of GAL in RA treatment and to elucidate its mechanisms of action. Overall, this review provides valuable insights into the potential of GAL as a therapeutic option for RA, shedding light on its multifaceted pharmacological properties and mechanisms of action, while suggesting avenues for future research and clinical applications.

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Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome

Cited by 3 publications

References 54 publications

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders

Galangin: A Promising Flavonoid for the Treatment of Rheumatoid Arthritis—Mechanisms, Evidence, and Therapeutic Potential

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