Co-operative controls of NOX and VOC are increasingly
emphasized to mitigate both PM2.5 and O3 pollution
in China. Given the substantial reductions in air pollutants expected
under carbon neutrality, both PM2.5 and O3 concentrations
will ultimately decrease to low levels regardless of co-operative
controls. Therefore, understanding the cost-effectiveness of co-operative
controls in the context of carbon neutrality is critical to enhance
the feasibility of implementing relevant policies. Here we evaluate
the control costs and health benefits under four co-operative control
strategies. We show that adopting co-operative controls in megacity
clusters can generate significant net benefits (health benefits minus
control cost), such as Beijing-Tianjin-Hebei and its surroundings
(net benefits: 0.23 trillion USD) and the Yangtze River Delta (net
benefits: 0.12 trillion USD), while the merit of adopting co-operative
controls nationwide is unnoticeable. Furthermore, these benefit increments
induced by co-operative controls are not considerable compared to
the benefits induced by carbon neutrality itself. The role of co-operative
controls deserves reconsideration in alignment with carbon neutrality,
with a focus on some specific regions rather than uniform implementation
across all cities.