Mitigating cadmium accumulation and toxicity in plants: The promising role of nanoparticles

Soni, Sunil; Jha, Ambuj Bhushan; Dubey, Rama Shanker; Sharma, Pallavi

doi:10.1016/j.scitotenv.2023.168826

Cited by 9 publications

(1 citation statement)

References 190 publications

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“…Heavy metal pollution, typi ed by Cd, is silently threatening human health. Cd has a fast migration rate and a long half-life, typically accumulating in the human body through the food chain (5). Prolonged accumulation of Cd can easily lead to diseases such as lung cancer, kidney cancer, and "itai-itai disease"(6, 7).…”

Section: Introductionmentioning

confidence: 99%

Co-selection of low cadmium accumulation and high yield during tomato breeding

Zhang,

Qing

et al. 2024

Preprint

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Enhancing crop production and yield is necessary to feed an increasing population but cadmium (Cd) accumulation in crops poses a serious threat to human health. We found that there has been a trend during domestication for co-selection of improved tomato yield and reduced Cd accumulation. A genome-wide association study (GWAS) of 506 tomato accessions identified a natural allele, SlF3’HAA, which confers low Cd accumulation in the shoots of tomato. The linkage disequilibrium (LD) analysis revealed a tight linkage between SlF3’HAA and a fruit weight gene fw3.2. Evolution analysis showed that fw3.2 and SlF3’H experienced similar selection pressure. These findings indicate that the widespread presence of low Cd accumulating types in cultivated tomato is due to genetic hitchhiking and co-selection of SlF3’H with fw3.2 during yield breeding.

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Section: Introductionmentioning

confidence: 99%

Co-selection of low cadmium accumulation and high yield during tomato breeding

Zhang,

Qing

et al. 2024

Preprint

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Knockout of OsHMA3 in an indica rice increases cadmium sensitivity and inhibits plant growth

Yan,

Jiao,

Chen

et al. 2024

Plant Growth Regul

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Cadmium (Cd) is a heavy metal that poses harm to both plants and humans. OsHMA3, a member of the heavy metal ATPase (HMA) family, plays a crucial role in sequestering Cd into the vacuoles of roots, thereby limiting its accumulation in rice grains. However, the response of rice plants to Cd under complete loss-of-function of OsHMA3 remains unclear. In this study, we successfully generated OsHMA3 null mutants in an indica variety 93 − 11 using CRISPR/Cas9 technology. A Cd resistance experiment revealed that the Oshma3 mutants exhibited increased sensitivity to Cd compared to the wild-type at a tested concentration of 10 µM CdCl2. Furthermore, the seedlings of Oshma3 mutant lines displayed inhibited plant growth in the presence of 1 µM Cd, specifically suppressing aboveground growth. As expected, knockout lines of OsHMA3 showed lower Cd accumulation in roots but higher concentrations in shoots compared to wild-type plants, highlighting the role of OsHMA3 in root-to-shoot Cd translocation. We further performed RNA sequencing analysis on wild-type and Oshma3 plants under control and Cd treatment conditions and found that differentially expressed genes were mainly enriched in metal ion binding, integral component of the membranes, and biosynthesis pathways for secondary metabolites triggered by exposure to Cd. When grown in a paddy field, the Oshma3 mutants exhibited shorter plant height, lower seed setting rate, and higher Cd accumulation in grains compared to wild-type plants. Our results indicate that knockout of OsHMA3 in the 93 − 11 variety increases sensitivity to Cd and inhibits plant growth.

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