Misuse and abuse of quetiapine

Piróg-Balcerzak, Agnieszka; Habrat, Bogusław; Mierzejewski, Paweł

doi:10.12740/pp/32923

Cited by 18 publications

(10 citation statements)

References 29 publications

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“…Quetiapine has unique sedative and anxiolytic effects due to its antagonistic effect on H 1 receptors and serotonin receptors, respectively. This drug effect profile has resulted in quetiapine's frequent use with stimulants such as amphetamines and cocaine to reduce the feelings of anxiety that come with using stimulants (23). By controlling the adverse effects associated with stimulant use, we suspect this can lead to higher drug doses and higher risk of mortality.…”

Section: Discussionmentioning

confidence: 99%

Multiple drug arrests reported to the Maine Diversion Alert Program more frequently involved carisoprodol, amitriptyline, or quetiapine

Siddiqui

Patel

et al. 2021

Preprint

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Background: Much of the blame of the increasing death toll by drug overdoses has justifiably been attributed to the United States current opioid epidemic. However, nearly 80% of overdoses related to opioids involve another drug substance or alcohol. The objective of this study was to elucidate overrepresentation of drugs in polypharmacy arrests by identifying drugs that were more likely to be found in conjunction with other substances, using the drug arrest data provided by the Maine Diversion Alert Program (DAP). Methods: Single drug arrest and multiple drug arrest totals reported to the DAP were examined. Drugs involved in the arrests were classified by Drug Enforcement Administration Schedule (I-V or non-controlled prescription) and categorized into five drug families: hallucinogens, opioids, sedatives, stimulants, and miscellaneous. Multiple drug arrest totals were compared to single drug arrest totals to create a Multiple-to-Single Ratio (MSR) specific to each drug family and each drug. Chi-square approximations without Yates correction and two-tailed P values were used to determine statistical significance through GraphPad 2x2 contingency tables. Results: Over three-fifths (63.8%) of all arrests involved a single drug. Opioids accounted for over-half (53.5%) of single arrests, followed by stimulants (27.7%) and hallucinogens (7.7%). Similarly, nearly two-fifths (39.6%) of multiple arrests were opioids, followed by stimulants (30.8%) and miscellaneous (13.0%). Miscellaneous family drugs were recorded with the highest Multiple-to-Single Ratio (1.51), followed by sedatives (1.09), stimulants (0.63), opioids (0.42), and hallucinogens (0.35). Carisoprodol (8.80), amitriptyline (6.34), and quetiapine (4.69) had the highest MSR values and therefore were the three most overrepresented drugs in polysubstance arrests. Conclusion: The abuse of opioids, both alone and in conjunction with another drug, deserves continued surveillance in public health. In addition, common prescription drugs with lesser-known misuse potential, especially carisoprodol, amitriptyline, and quetiapine, require more attention by medical providers for their ability to enhance the effects of other drugs or to compensate for undesired drug effects.

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Section: Discussionmentioning

confidence: 99%

Multiple drug arrests reported to the Maine Diversion Alert Program more frequently involved carisoprodol, amitriptyline, or quetiapine

Siddiqui

Patel

et al. 2021

Preprint

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“…The recreational misuse of SGAs has been widely reported, quetiapine being the most common, followed by risperidone and olanzapine [ 3 ]. There have been numerous reports of prisoners feigning psychotic symptoms to obtain quetiapine and use its powder intranasally [ 11 ]. This popularity of SGAs over FGAs has been explained by the milder side effect profile of SGAs, more specifically a lower propensity to cause EPS.…”

Section: Discussionmentioning

confidence: 99%

Acute Extrapyramidal Side Effects from Smoked Haloperidol

Pham

Lee

Miller

2021

Case Reports in Psychiatry

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Introduction. Haloperidol is a dopamine receptor antagonist used to treat patients with psychotic disorders. Especially at high doses, haloperidol carries a higher risk of extrapyramidal symptoms (EPS) compared to second-generation antipsychotics. Few cases of haloperidol misuse are found in the medical literature. Case Presentation. We describe a patient with schizophrenia who smoked marijuana mixed with crushed haloperidol tablets. After the smoking of cannabis and haloperidol, the patient presented to the emergency department (ED) with suicidal ideation, psychosis, and acute dystonia. With the administration of intramuscular diphenhydramine at the ED, the dystonia resolved in less than an hour. To our knowledge, this is the first report on haloperidol misuse by smoking. Conclusion. Clinicians should be aware that patients might misuse prescribed antipsychotics via unconventional routes, potentially combined with other substances.

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“…Antagonism to α 1 adrenergic and histamine H 1 receptor results in side effects like sedation and orthostatic hypotension. Moreover, there are reports about quetiapine misuse and abuse which can be linked with its high affinity for the H 1 receptor, as antihistamines agents cause rewarding action, compare Figure 3 [ 96 ].…”

Section: Multi-target Compounds To Treat Schizophreniamentioning

confidence: 99%

Multi-Target Approach for Drug Discovery against Schizophrenia

Kondej

Stępnicki

Kaczor

2018

IJMS

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Polypharmacology is nowadays considered an increasingly crucial aspect in discovering new drugs as a number of original single-target drugs have been performing far behind expectations during the last ten years. In this scenario, multi-target drugs are a promising approach against polygenic diseases with complex pathomechanisms such as schizophrenia. Indeed, second generation or atypical antipsychotics target a number of aminergic G protein-coupled receptors (GPCRs) simultaneously. Novel strategies in drug design and discovery against schizophrenia focus on targets beyond the dopaminergic hypothesis of the disease and even beyond the monoamine GPCRs. In particular these approaches concern proteins involved in glutamatergic and cholinergic neurotransmission, challenging the concept of antipsychotic activity without dopamine D2 receptor involvement. Potentially interesting compounds include ligands interacting with glycine modulatory binding pocket on N-methyl-d-aspartate (NMDA) receptors, positive allosteric modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, positive allosteric modulators of metabotropic glutamatergic receptors, agonists and positive allosteric modulators of α7 nicotinic receptors, as well as muscarinic receptor agonists. In this review we discuss classical and novel drug targets for schizophrenia, cover benefits and limitations of current strategies to design multi-target drugs and show examples of multi-target ligands as antipsychotics, including marketed drugs, substances in clinical trials, and other investigational compounds.

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Misuse and abuse of quetiapine

Cited by 18 publications

References 29 publications

Multiple drug arrests reported to the Maine Diversion Alert Program more frequently involved carisoprodol, amitriptyline, or quetiapine

Multiple drug arrests reported to the Maine Diversion Alert Program more frequently involved carisoprodol, amitriptyline, or quetiapine

Acute Extrapyramidal Side Effects from Smoked Haloperidol

Multi-Target Approach for Drug Discovery against Schizophrenia

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