2018
DOI: 10.1021/acs.cgd.8b01487
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Missing Link in the Homologous Series of Lactams: The X-ray Structure of Valerolactam

Abstract: Lactams are an important class of heterocyclic compounds and are widely used for industrial and pharmaceutical purposes. Even decades after initial lactam syntheses, research on their physical and chemical properties is still rewarding. It delivers valuable information on the reactivity of lactams and their conformational behavior. For the small- and medium-sized parent lactams, the X-ray structures have been well-known, except for the “missing link”, the six-membered valerolactam. An X-ray structure of valero… Show more

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Cited by 2 publications
(8 citation statements)
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“…The ester moiety is in a clear equatorial position (Figure 6a). As observed for the parent valerolacta m (CSD code: HIQJOJ) 11 (Fig. 6c).…”
Section: Resultssupporting
confidence: 65%
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“…The ester moiety is in a clear equatorial position (Figure 6a). As observed for the parent valerolacta m (CSD code: HIQJOJ) 11 (Fig. 6c).…”
Section: Resultssupporting
confidence: 65%
“…The ester moiety is in a clear equatorial position (Figure a). As observed for the parent valerolactam (CSD code: HIQJOJ) two molecules of 5 form an R 2 2 (8) amide dimer via N–H···O hydrogen bonds (Figure b). The dimerized lactams are connected via C–H···O interactions between C4 and the carbonyl oxygen forming bands in the direction of the b axis.…”
Section: Resultsmentioning
confidence: 72%
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