Missing cell types in single-cell references impact deconvolution of bulk data but are detectable
Adriana Ivich,
Natalie R. Davidson,
Laurie Grieshober
et al.
Abstract:Advancements in RNA-sequencing have dramatically expanded our ability to study gene expression profiles of biological samples in bulk tissue and single cells. Deconvolution of bulk data with single-cell references provides the ability to study relative cell-type proportions, but most methods assume a reference is present for every cell type in bulk data. This is not true in all circumstances--cell types can be missing in single-cell profiles for many reasons. In this study, we examine the impact of missing cel… Show more
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