“…Neuron-specific isoform expression is essential to proper cell-type specification as shown from recent studies in neuronal development (Furlanis and Scheiffele, 2018;Saito et al, 2019;Schwartzentruber et al, 2018), disease (Gandal et al, 2018;de la Torre-Ubieta et al, 2016;Parikshak et al, 2016;Voineagu et al, 2011) and activity Parikshak et al, 2016;Quesnel-Vallières et al, 2016). While many neurological diseases, including autism (Quesnel-Vallières et al, 2016;Voineagu et al, 2011), Rett syndrome (Cheng et al, 2017;Kriaucionis and Bird, 2004;Li et al, 2016), Huntington's disease (Lin et al, 1993;Sathasivam et al, 2013;Wood, 2013), spinal muscular atrophy (Cartegni et al, 2006;Lorson et al, 1999;Parente and Corti, 2018;Xiong et al, 2015) and schizophrenia (Gandal et al, 2018;Glatt et al, 2011;Morikawa and Manabe, 2010;Nakata et al, 2009;Wu et al, 2012) have been linked to disruptions in alternative splicing, this mechanism of gene regulation is understudied in the context of drug abuse and addiction. Only one study thus far has reported that investigator administered cocaine results in greater changes in isoform expression than gene expression in the NAc (Feng et al, 2014).…”