Misperceptions of ovarian cancer risk in women at increased risk for hereditary ovarian cancer

Meiser, Bettina; Price, Melanie A.; Butow, Phyllis; Rahman, Belinda; Tucker, Kathy; Cheah, Benjamin C.; Bickerstaffe, Adrian; Hopper, John L.; Phillips, Kelly‐Anne

doi:10.1007/s10689-013-9687-y

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Cull et al 23 found that the best predictor of risk overestimation in a sample of women with a family history of ovarian cancer was anxiety, with their health behavior being guided by anxiety rather than objective risk. Meiser et al 24 found that women at increased genetic risk with higher levels of specific anxiety for cancer were more likely to overestimate the risk of ovarian cancer, especially if they had a mother diagnosed with the disease. Ultimately, the cited studies highlight the importance of considering anxiety as a key factor in cancer‐related risk perception and suggest the need for tailored interventions to reduce anxiety and prevent risk overestimation.…”

Section: Discussionmentioning

confidence: 99%

Breast/ovarian cancer genetic counseling: Do anxiety, depression, and health care‐related fears influence cancer worry and risk perception?

Caruso,

Maggi,

Vigna

et al. 2023

Cancer Medicine

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BackgroundThe impact of family and personal cancer history and emotional factors, such as depression and anxiety, on disease representation has received limited attention in studies investigating the development of cancer‐related worry and risk perception within the context of genetic counseling. The current study endeavors to fill this gap by exploring the extent to which depression and anxiety influence cancer worry and risk perception, and the role of health care‐related fear as potential mediator in this relationship.MethodsA sample of 178 women who underwent their first genetic counseling for breast/ovarian cancer, 52% of whom had previous cancer diagnoses, completed questionnaires assessing sociodemographic and clinical information, emotional distress in terms of anxiety and depression, cancer‐related worry, risk perception, and health care‐related fears.ResultsResults of mediation analyses showed that cancer‐related worry and risk perception increased with rising levels of depression and anxiety, with health care‐related fears acting as a mediator in the relationship of depression and anxiety with cancer worry and risk perception. Covariate analysis revealed that previous cancer diagnosis increases cancer‐related worry but not risk perception, while the number of family members affected by cancer increases both outcomes.ConclusionThese findings emphasize the need for a holistic approach in genetic counseling and have implications for the clinical practice.

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Section: Discussionmentioning

confidence: 99%

Breast/ovarian cancer genetic counseling: Do anxiety, depression, and health care‐related fears influence cancer worry and risk perception?

Caruso,

Maggi,

Vigna

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…Cancer genetic counseling is performed by a multidisciplinary team including dedicated oncologist and psychologist, according to the multistep model designed and validated within the Italian Network for “Hereditary Breast and/or Ovarian Cancer”. Structured sessions with a psycho-oncologist for psychological assessment, psychological counseling interventions and psychotherapy or emotional support are also planned for patients and their at-risk subjects [6, 9]. During the cancer genetic counseling steps devoted to information-giving and pedigree construction, anxiety and depression levels were assessed from replies to self-report questionnaire administered by the psycho-oncologist.…”

Section: Methodsmentioning

confidence: 99%

Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer

Pensabene

Condello

Carlomagno

et al. 2016

Hered Cancer Clin Pract

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BackgroundEarly-onset or hereditary ovarian cancer is mostly associated with BRCA1 or BRCA2 mutations. Mismatch repair genes sequence alteration frequently cause colorectal cancer, and, in less extent, other tumors, such as ovarian cancer. Subjects with personal and/or family history suggestive for hereditary cancer should be addressed to cancer genetic counseling, aimed to the identification, definition and management of hereditary cancer syndrome, by a multidisciplinary approach.Case presentationA woman with a very early onset epithelial ovarian cancer underwent to cancer genetic counseling and genetic testing. Pedigree analysis suggested a clinical diagnosis of Lynch II syndrome, according to the Amsterdam criteria. The MMRpro model showed a cumulative risk of mutation of 50.3 %, thus, genetic testing was offered to the patient. Two germ-line mutations have been identified in exon 11 of MSH2 gene: c.1706A > T (p.Glu569Val) and c.1711G > T (p.Glu571*). Both DNA alterations were novel mutations not yet described in literature. The first is a missense mutation that is to be considered an unclassified variant; the second is nonsense mutation that created a premature stop codon resulting in a truncated not functioning protein. Both genetic alterations were found in the patients’ father DNA.ConclusionsThe present report finds out two unpublished sequence alterations in exon 11 of the MSH2 gene, one on which can be considered causative of Lynch phenotype. Moreover, it stresses the importance of the multidisciplinary onco-genetic counselling in order to correctly frame the hereditary syndrome, suggest the right genetic test, and offer the most appropriate management of the cancer risk for the patients and her family members.

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Decision-making for Risk-reducing Salpingo-oophorectomy (RRSO) in Southeast Asian BRCA Mutation Carriers With Breast Cancer: A Qualitative Study

et al. 2021

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Misperceptions of ovarian cancer risk in women at increased risk for hereditary ovarian cancer

Abstract: Background: This study assessed the sociodemographic, medical and psychological

Cited by 5 publications

References 45 publications

Breast/ovarian cancer genetic counseling: Do anxiety, depression, and health care‐related fears influence cancer worry and risk perception?

Breast/ovarian cancer genetic counseling: Do anxiety, depression, and health care‐related fears influence cancer worry and risk perception?

Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer

Decision-making for Risk-reducing Salpingo-oophorectomy (RRSO) in Southeast Asian BRCA Mutation Carriers With Breast Cancer: A Qualitative Study

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