Misoprostol for cervical priming prior to hysteroscopy in postmenopausal and premenopausal nulliparous women: A multicentre randomised placebo controlled trial

Electronic Continuous Pain Measurement vs Verbal Rating Scale in gynaecology: A prospective cohort study

“…In addition, non-pharmacological effects on pain can be studied in detail, such as the presence of a nurse guiding the patient, or the use of music or images. Work has already commenced on this by the authors' study group, comparing two types of gels used during gel infusion sonography, and a comparative study was performed using misoprostol vs placebo before hysteroscopy to determine the effect on pain [25]. For years, efforts have been made, in vain, to discover the best method for pain reduction in outpatient procedures, especially during hysteroscopy.…”

Authors' reply re: Misoprostol for cervical priming prior to hysteroscopy in postmenopausal and premenopausal nulliparous women; a multi‐centre randomised placebo controlled trial

“…Misoprostol proved to reduce pain in nulliparous premenopausal women undergoing a hysteroscopy. As Mr Kesrouani correctly points out, adverse effects occurred significantly more often in this group compared with placebo: more nausea (17% [misoprostol] versus 11% [placebo]) as well as abdominal pain (24% [misoprostol] versus 15% [placebo]) . His dose‐finding study was able to demonstrate a relation between dosage and adverse effects: higher rates of nausea (11% [400 micrograms] versus 6% [200 micrograms]) and abdominal pain (25% [400 micrograms] versus 13% [200 micrograms]) …”

“…We would like to take the opportunity to thank Mr Kesrouani for his positive response to our paper, published in the January issue of BJOG . We referred to his thorough, dose‐finding randomised trial in our discussion, regarding the possibility of using a lower dose of misoprostol …”

“…In fact, they were significantly more likely to undergo the procedure again (95% versus 62%) without additional anaesthesia (100% versus 62%) and would recommend the procedure to a friend (85% versus 52%). Apparently, perceived pain is more important than reported adverse effects …”

Re: Misoprostol for cervical priming prior to hysteroscopy in postmenopausal and premenopausal nulliparous women: a multicentre randomised placebo controlled trial

“…The paper by Tasma et al . examined the reduction of pain by misoprostol compared with placebo prior to hysteroscopy and evaluated the difference in premenopausal and postmenopausal patients.…”