Misoprostol alleviates paclitaxel-induced liver damage through its antioxidant and anti-apoptotic effects

Gür, Fatih Mehmet; Aktaş, İbrahim; Bilğiç, Sedat; Pekince, Merve

doi:10.1007/s13273-021-00210-0

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…In addition, it has been proven in many studies that antioxidant compounds prevent oxidative stress and inflammation in Cis-induced kidney damage (35)(36)(37)(38). In this study, increased serum BUN and Cr concentrations, increased MDA levels, decreased antioxidant enzyme activities and GSH levels show that kidney damage occurs as a result of Cis administration.…”

Section: Discussionmentioning

confidence: 54%

“…Previous studies have shown that many pharmacological agents with antioxidant effects can be used successfully to prevent the toxic effects of anticancer drugs (Cis, paclitaxel) in non-target tissues (4)(5)(6)22,38). L, which has antioxidant effects, probably protects the kidney tissue from the harmful effects of oxidative stress by preventing the oxidative stress-increasing effects of Cis thanks to these effects.…”

Section: Discussionmentioning

confidence: 99%

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Sisplatin’e Maruz Bırakılan Sıçan Böbreğinde Lutein’in Koruyucu Etkisinin Biyokimyasal ve Histopatolojik Olarak İncelenmesi

Bilğiç

Gür²,

Aktaş

2022

Medical Records

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Amaç: Çalışmamızda, erkek sıçanlarda sisplatin (Cis) (10 mg/kg, intraperitoneal) kaynaklı böbrek hasarına karşı lutein’in (L) (100 mg/kg, oral) koruyucu etkisi incelendi. Materyal ve Metot: Bu çalışmada, 8-9 haftalık Sprague Dawley türü 28 adet sıçan kullanıldı. Sıçanlar rastgele her grupta 7 tane olacak şekilde 4 gruba ayrıldı: Kontrol, L, Cis ve Cis + L. Bulgular: Biyokimyasal bulgulara göre, Cis grubunun kontrol grubu ile kıyaslanmasında serum kreatinin (Cr) ve kan üre nitrojen (BUN) seviyelerinin anlamlı düzeyde arttığı görüldü (p < 0.05). Cis + L grubunda serum Cr ve BUN düzeylerinin Cis grubuna kıyasla anlamlı düzeyde azaldığı tespit edildi (p < 0.05). Ayrıca Cis + L grubunun Cis grubu ile kıyaslanmasında malondialdehit (MDA) seviyesinde düşüş, glutatyon (GSH), süperoksit dismutaz (SOD) ve katalaz (CAT) seviyelerinde ise artış kaydedildi (p < 0.05). Yapılan histopatolojik incelemelerde Cis grubu sıçanların böbrek dokularında interstisyel mononükleer lökosit infiltrasyonu, tubuler dejenerasyon ve tubuler nekroz gibi patolojik değişiklikler gözlendi. Cis + L grubunda, Cis grubuna nazaran oksidatif stresin azaldığı, antioksidan aktivitenin arttığı ve histopatolojik değişikliklerin azaldığı görüldü. Sonuç: Bu sonuçlar L'nin Cis kaynaklı böbrek hasarının önlenmesinde etkili olduğunu göstermektedir. Ayrıca L'nin bu hasarda kullanılma potansiyeli olan bir farmakolojik ajan olduğuda ortaya çıkmaktadır.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Sisplatin’e Maruz Bırakılan Sıçan Böbreğinde Lutein’in Koruyucu Etkisinin Biyokimyasal ve Histopatolojik Olarak İncelenmesi

Bilğiç

Gür²,

Aktaş

2022

Medical Records

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Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation

Khaled

Soliman

Abdel‐Gabbar

et al. 2023

Environ Sci Pollut Res

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This research aimed to evaluate the preventing effects of naringin, naringenin, and their combination on liver injury induced by Taxol (paclitaxel) in Wistar rats. Male Wistar rats received 2 mg/kg Taxol intraperitoneal injections twice weekly on the second and fifth days of each week for 6 weeks. During the same period as Taxol administration, rats were given naringin, naringenin, or a combination of the two (10 mg/kg b.wt) every other day. Treatment with naringin and/or naringenin reduced the abnormally high serum levels of total bilirubin, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma-glutamyl transferase in Taxol-treated rats. It also significantly increased the level of serum albumin, indicating an improvement in the liver. The perturbed histological liver changes were markedly improved due to the naringin and/or naringenin treatment in Taxol-administered rats. Additionally, the treatments reduced high hepatic lipid peroxidation and increased liver glutathione content as well as the activities of superoxide dismutase and glutathione peroxidase. Furthermore, the treatments reduced the levels of alpha-fetoprotein and caspase-3, a pro-apoptotic mediator. The naringin and naringenin mixture appeared more effective in improving organ function and structural integrity. In conclusion, naringin and naringenin are suggested to employ their hepatoprotective benefits via boosting the body’s antioxidant defense system, reducing inflammation, and suppressing apoptosis. Graphical Abstract

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Salvia microphylla essential oil reduces cell viability in cisplatin-resistant clear cell type ovarian cancer cells caused by mitochondrial dysfunction

Jang,

Jo,

Lim

et al. 2024

Mol. Cell. Toxicol.

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Misoprostol alleviates paclitaxel-induced liver damage through its antioxidant and anti-apoptotic effects

Cited by 8 publications

References 41 publications

Sisplatin’e Maruz Bırakılan Sıçan Böbreğinde Lutein’in Koruyucu Etkisinin Biyokimyasal ve Histopatolojik Olarak İncelenmesi

Sisplatin’e Maruz Bırakılan Sıçan Böbreğinde Lutein’in Koruyucu Etkisinin Biyokimyasal ve Histopatolojik Olarak İncelenmesi

Naringin and naringenin counteract taxol-induced liver injury in Wistar rats via suppression of oxidative stress, apoptosis and inflammation

Salvia microphylla essential oil reduces cell viability in cisplatin-resistant clear cell type ovarian cancer cells caused by mitochondrial dysfunction

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