Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex

Kropotov, J.D.; Nääänen, R.; Sevostianov, Andrei; Alho, Kimmo; Reinikainen, K.; Kropotova, O.V.

doi:10.1111/j.1469-8986.1995.tb01226.x

Cited by 168 publications

(81 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, generators for the MMN are thought to be from the auditory cortex (Kropotov et al, 1995) with physical separation of foci for processing of pitch and duration (Molholm et al, 2005), similar to the current findings. Some workers have also noted activation from frontal generators thought to reflect a shift of attention toward the deviant, although recent work suggests that the role of the frontal generator may not depend on attention requirements (Shalgi and Deouell, 2007).…”

Section: Discussionsupporting

confidence: 83%

“…Specifically, Pick-Atlas defined ROI masks were applied and peak t values were generated for left and right Brodmann Areas 41, 42, and STG for the deviant condition (three regions of interest (ROI) per side per experiment, 12 in total). These regions were selected a priori as they likely are the regions involved in tone processing (Yoo et al, 2005;Kropotov et al, 1995;Alho, 1995). Note that Brodmann Area 41 derived from PickAtlas does not directly correspond to the manual Heschl's drawing above.…”

Section: Fmri Statistical Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

View full text Add to dashboard Cite

Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Fmri Statistical Methodsmentioning

confidence: 99%

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…With EEG, MMN is often measured over frontal sites. Sources of the signal have been identified bilaterally in the supratemporal plane, as well as in the right frontal lobe (e.g., Deouell et al, 1998;Giard et al, 1990;Kasai et al, 1999;Kropotov et al, 1995;Levänen et al, 1996;Rinne et al, 2000). Importantly, MMN is not evoked under conditions of continuously changing stimuli, unless the so-called deviant is itself a repetition (repetition negativity, 1 e.g., Horváth and Winkler, 2004).…”

Section: Mismatch Negativitymentioning

confidence: 99%

A mismatch negativity study of local–global auditory processing

List¹,

Justus²,

Robertson³

et al. 2007

Brain Research

View full text Add to dashboard Cite

We used mismatch negativity (MMN) to examine structural encoding of local and global auditory patterns in perceptual memory. Unlike previous MMN studies of local-global auditory perceptual organization that used interval-contour stimuli, here we presented hierarchical stimuli in which local pattern organization formed global patterns. Importantly, our stimuli allowed independent manipulation of the two structural levels. In separate blocks, participants were exposed to frequent local standard patterns and rare local deviant patterns, or to frequent global standard patterns and rare global deviant patterns. Within each deviant pattern, the variation from the standard pattern could occur at onset (early), towards the end of the pattern (late) or over both time windows (both). To isolate pattern indexing at one level, the other level continuously changed (e.g., in a global standard block, local elements varied trial-by-trial). MMN was found only for global deviant patterns, and only when deviation occurred late in the pattern. In a separate behavioral experiment, global deviants were detected more often than local ones, although initial similarity followed by a late deviation from the standard pattern was not required for explicit deviant detection (as with the MMN). This report demonstrates neural structural encoding for global information, when independently manipulated from local information. Furthermore, it extends previous MMN findings that have revealed indexing of complex abstract auditory information to the realm of hierarchical perceptual organization.

show abstract

“…Similarly, mismatch potentials recorded from temporal (mastoid) and frontal electrodes partially may originate from different sources, despite the polarity inversion typical for a single dipole source in the superior temporal plane. This was based on studies of MMN scalp topography (Giard et al, 1990(Giard et al, , 1995Baldeweg et al, 1999Baldeweg et al, , 2002Rinne et al, 2000) and developmental changes (Gomot et al, 2000) and intracranial recordings in humans Halgren et al, 1995;Kropotov et al, 1995;Liasis et al, 2001;Rosburg et al, 2005). This dissociation was also visible here, showing ERP repetition effects in frontal but not in temporal electrodes in the passive condition.…”

Section: Neural Generators Of Rpmentioning

confidence: 99%

Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Haenschel

Вернон²,

Dwivedi³

et al. 2005

J. Neurosci.

249

265

View full text Add to dashboard Cite

The event-related potential (ERP) component mismatch negativity (MMN) is a neural marker of human echoic memory. MMN is elicited by deviant sounds embedded in a stream of frequent standards, reflecting the deviation from an inferred memory trace of the standard stimulus. The strength of this memory trace is thought to be proportional to the number of repetitions of the standard tone, visible as the progressive enhancement of MMN with number of repetitions (MMN memory-trace effect). However, no direct ERP correlates of the formation of echoic memory traces are currently known. This study set out to investigate changes in ERPs to different numbers of repetitions of standards, delivered in a roving-stimulus paradigm in which the frequency of the standard stimulus changed randomly between stimulus trains. Normal healthy volunteers (n ϭ 40) were engaged in two experimental conditions: during passive listening and while actively discriminating changes in tone frequency. As predicted, MMN increased with increasing number of standards. However, this MMN memory-trace effect was caused mainly by enhancement with stimulus repetition of a slow positive wave from 50 to 250 ms poststimulus in the standard ERP, which is termed here "repetition positivity" (RP). This RP was recorded from frontocentral electrodes when participants were passively listening to or actively discriminating changes in tone frequency. RP may represent a human ERP correlate of rapid and stimulus-specific adaptation, a candidate neuronal mechanism underlying sensory memory formation in the auditory cortex.

show abstract

Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex

Cited by 168 publications

References 16 publications

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

A mismatch negativity study of local–global auditory processing

Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Contact Info

Product

Resources

About