Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity

Pentz, Atle Bråthen; Timpe, Clara Maria Fides; Normann, Elizabeth Marie; Slapø, Nora Berz; Melle, Ingrid; Lagerberg, Trine Vik; Steen, Nils Eiel; Westlye, Lars T.; Jönsson, Erik G.; Haukvik, Unn K.; Moberget, Torgeir; Andreassen, Ole A.; Elvsåshagen, Torbjørn

doi:10.1016/j.schres.2023.09.012

Cited by 3 publications

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“…Understanding the in uence of biological sex on AC function and structure in SCZ spect may provide insight into the neural substrate behind the well-established sex differences in the pathophysiology and treatment response in SCZ spect 47,48 . While previous studies report sex differences in the ERP-P300 component 49 and in the mismatch negativity 50 in SCZ spect , studies investigating sex difference in the N100 amplitude are sparse [51][52][53] . While previous studies have reported sex difference in brain structure in SCZ spect 48 to our knowledge, no study has investigated sex difference in T1w/T2w-ratio in the AC in SCZ spect .…”

Section: Introductionmentioning

confidence: 94%

Relationship between N100 amplitude and T1w/T2w-ratio in the auditory cortex in schizophrenia spectrum disorders

Slapø,

Jørgensen,

Nerland

et al. 2024

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Schizophrenia spectrum disorders (SCZspect) are associated with altered function in the auditory cortex (AC), indicated by reduced N100 amplitude of the auditory evoked potential (AEP). While the neural substrate behind reduced N100 amplitude remains elusive, myelination in the AC may play a role. We compared N100 amplitude and magnetic resonance imaging (MRI) T1 weighted and T2 weighted ratio (T1w/T2w-ratio) as a proxy of myelination, in the primary AC (AC1) and secondary AC (AC2) between SCZspect (n = 33, 48% women) and healthy controls (HC, n = 144, 49% women). Further, we examined associations between N100 amplitude and T1w/T2w-ratios in SCZspect and HC. We finally explored N100 amplitude and T1w/T2w-ratios in the AC1/AC2 and association between N100 amplitude and T1w/T2w-ratios between male and female SCZspect and HC. N100 amplitude did not differ between SCZspect and HC or between female SCZspect and female HC, but was significantly reduced in male SCZspect compared to male HC (est = 4.3, se = 1.63, t = 2.63, p = 0.010). Further, T1w/T2w ratios in the AC1/AC2 did not differ between any groups. Finally, N100 amplitude was not associated with T1/T2-ratios in the AC1/AC2 in any groups. Reduced N100 amplitude in male SCZspect compared to male HC, suggest that sex-specific effects should be considered in research on SCZspect neurophysiology. Our findings did not support the hypothesis that reduced myelination in the AC1/AC2, as indexed by T1w/T2w-ratio, underlies N100 abnormalities in SCZspect. However, more precise estimates of intracortical myelin are needed to confirm this.

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