Mismatch Negativity in Chronic Schizophrenia and First-Episode Schizophrenia

Salisbury, Dean F.; Shenton, Martha E.; Griggs, Carlye B.; Bonner‐Jackson, Aaron; McCarley, Robert W.

doi:10.1001/archpsyc.59.8.686

Cited by 261 publications

(196 citation statements)

References 66 publications

(76 reference statements)

Supporting

Mentioning

166

Contrasting

Unclassified

Order By: Relevance

“…Deficits in early auditory sensory processing, including N1, MMN, and P300, have been shown using ERP in schizophrenic subjects (Baldeweg et al, 2004;Kasai et al, 2002;Salisbury et al, 1998;Javitt et al, 2000;Javitt et al, 1995;Elvevag et al, 2004), in prodromal subjects (Brockhaus-Dumke et al, 2005), and in SPD subjects (Salisbury et al, 1996;Niznikiewicz et al, 2000;Liu et al, 2007). Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Auditory sensory processing has been found to be impaired in schizophrenia (Salisbury et al, 1998;Javitt et al, 2000) and correlate with clinical features, particularly negative symptoms (Javitt et al, 2000), (Kasai et al, 2002) (Leitman et al, 2005) and cognitive impairment (Baldeweg et al, 2004). Abnormalities in the superior temporal gyrus (STG) have been implicated in the processing of pure tones, a fundamental element of complex sounds and language, using fMRI (Wible et al, 2001) and event-related potentials (Salisbury et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Abnormalities in the superior temporal gyrus (STG) have been implicated in the processing of pure tones, a fundamental element of complex sounds and language, using fMRI (Wible et al, 2001) and event-related potentials (Salisbury et al, 1998). Hallucinations, which may be considered an error in auditory sensory processing, have been associated with the STG (Dierks et al, 1999) (Cleghorn et al, 1992), with the STG more activated during hallucinations than actual speech (David et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

“…A MMN ERP paradigm, which elicits an early negative deflection following a deviant stimulus, results in a less negative deflection in schizophrenic subjects and has been used frequently to assess subjects' pre-attentive ability to detect changes in tone features (e.g. : Salisbury et al, 1998). In contrast, to our knowledge (Medline search 1/10/08), there have been only two published fMRI experiments utilizing the mismatch design in patients with schizophrenia (Wible et al, 2001;Kircher et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…Patients with schizophrenia show stable, consistent deficits in MMN that also are associated with global assessment of everyday functioning [31]. Salisbury et al [32] showed that MMN deficits were not present in first-episode schizophrenia patients at initial assessment, but these deficits evolved over time. The possibility that MMN may be an index of later neurodevelopmental abnormalities in the early stages of schizophrenia suggests its potential utility in the study of the schizophrenia prodrome.…”

Section: Mismatch Negativity Paradigmmentioning

confidence: 99%

Progress in the prospective study of the schizophrenia prodrome

Fu¹,

Cadenhead

2005

Current Psychosis & Therapeutics Reports

View full text Add to dashboard Cite

Further understanding of the schizophrenia spectrum has helped to define the prodrome of the illness, leading to hopes of earlier identification and intervention in susceptible, at-risk individuals. Given the heterogeneity and comorbidity observed in the clinically and demographically identified prodromal sample, it is essential that neurobiological markers that are more closely linked to brain function, and perhaps the ability to predict evolution of psychosis, be identified. Ultimately, it may be possible to identify an algorithm of risk factors that will combine clinical and demographic risk factors with vulnerability markers associated with later development of schizophrenia to better target at-risk individuals or preventative treatment.

show abstract

Probing Thalamic Integrity in Schizophrenia Using Concurrent Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging

Guller¹,

Ferrarelli²,

Shackman³

et al. 2012

Arch Gen Psychiatry

View full text Add to dashboard Cite

Context Schizophrenia is a devastating illness with an indeterminate pathophysiology. Several lines of evidence implicate dysfunction in the thalamus, a key node in the distributed neural networks underlying perception, emotion, and cognition. Existing evidence of aberrant thalamic function is based on indirect measures of thalamic activity, but dysfunction has not yet been demonstrated with a causal method. Objective Test the hypothesis that direct physiological stimulation of cortex will produce an abnormal thalamic response in individuals with schizophrenia. Design We stimulated the precentral gyrus with single-pulse transcranial magnetic stimulation (spTMS) and measured the response to this pulse in synaptically-connected regions (thalamus, medial superior frontal cortex [mSFG], insula) using concurrent functional magnetic resonance imaging (fMRI). The mean hemodynamic response from these regions was fit with the sum of two gamma functions and response parameters were compared across groups. Setting Academic research laboratory. Participants Patients with schizophrenia and sex- and age- matched psychiatrically healthy subjects were recruited from the community. Main Outcome Measures Peak amplitude of the thalamic hemodynamic response to spTMS of precentral gyrus. Results spTMS-evoked responses did not differ between groups at the cortical stimulation site. Compared to healthy subjects, schizophrenia patients showed a reduced response to spTMS in the thalamus (P=1.86 × 10−9) and mSFG (P=.02). Similar results were observed in the insula. Sham TMS indicated that these results could not be attributed to indirect effects of TMS coil discharge. Functional connectivity analyses revealed weaker thalamus-mSFG and thalamus-insula connectivity in schizophrenia patients compared to control subjects. Conclusions Individuals with schizophrenia showed reduced thalamic activation in response to direct perturbation delivered to the cortex. These results extend prior work implicating the thalamus in the pathophysiology of schizophrenia and suggest that the thalamus contributes to the patterns of aberrant connectivity characteristic of this disease.

show abstract

Mismatch Negativity in Chronic Schizophrenia and First-Episode Schizophrenia

Cited by 261 publications

References 66 publications

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Progress in the prospective study of the schizophrenia prodrome

Probing Thalamic Integrity in Schizophrenia Using Concurrent Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging

Contact Info

Product

Resources

About