2012
DOI: 10.1016/j.clinph.2012.03.011
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Mismatch negativity and low frequency oscillations in schizophrenia families

Abstract: Objective Theta-alpha range oscillations have been associated with MMN in healthy controls. Our previous studies showed that theta-alpha activities are highly heritable in schizophrenia patients’ families. We aimed to test the hypothesis that theta-alpha activities may contribute to MMN in schizophrenia patients and their family members. Methods We compared MMN and single trial oscillations during MMN in 95 patients, 75 first-degree relatives, 87 controls, and 34 community subjects with schizophrenia spectru… Show more

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Cited by 44 publications
(36 citation statements)
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“…The event-related potential and MRS methods have been described previously, 33,36,52 and details are given in the eMethods in the Supplement. Briefly, the event-related potential was recorded using a 64-channel system 2 (SynAmps; Compumedics Neuroscan) at a 1-kHz sampling rate with bandpass at 0.1 to 200 Hz.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The event-related potential and MRS methods have been described previously, 33,36,52 and details are given in the eMethods in the Supplement. Briefly, the event-related potential was recorded using a 64-channel system 2 (SynAmps; Compumedics Neuroscan) at a 1-kHz sampling rate with bandpass at 0.1 to 200 Hz.…”
Section: Methodsmentioning
confidence: 99%
“…The paradigm was a passive duration-deviant odd-ball task. 52 Standard and deviant trials were averaged separately, followed by subtraction of the 2 mean waveforms. Mismatch negativity was scored by peak detection within a poststimulus window of 100 to 225 milliseconds by an automatic algorithm, followed by visual inspection to verify correct placement of each marker for peak detection.…”
Section: Methodsmentioning
confidence: 99%
“…MMN has been positioned as a potentially promising biomarker candidate for the diagnosis of pathologies such as schizophrenia (Harms et al, 2014;Nagai et al, 2013) or autism spectrum disorders, including Asperger's syndrome (e.g., O'Connor, 2012). Patients with schizophrenia exhibited a reduced ability to detect acoustic changes reflected in reduced MMN (Fisher, Grant, Smith, Borracci, Labelle, & Knott, 2012;Hong, Moran, Du, O'Donnell, & Summerfelt, 2012;Michie, 2001). Schizophrenia has been associated with alterations in neurotransmission as the one mediated by the NMDA (N-methyl-d-aspartate) receptor (Matsuno et al, 2015).…”
Section: Overviewmentioning
confidence: 99%
“…64 ). By contrast, we 34 and others 35,36,65 have linked MMN deficits to impaired theta-frequency response, and underlying NMDAR dysfunction in rodent 66,67 and primate 28 models. At the local circuit level, theta rhythms are tied to interactions involving non-PV cells, especially somatostatintype inhibitory interneurons 6,29,68 .…”
Section: Theta Frequency and Ensemble Activity Within Auditory Regionsmentioning
confidence: 99%
“…We 34 and others 35,36 have previously linked MMN dysfunction in schizophrenia primarily to impaired theta frequency response. In the present study we investigate alpha-frequency activation to standard stimuli as well.…”
Section: Introductionmentioning
confidence: 99%