Mismatch negativity abnormality in traumatic brain injury without macroscopic lesions on conventional MRI

Kaipio, Marja-Liisa; Cheour, Marie; Öhman, Juha; Salonen, Oili; Näätänen, Risto

doi:10.1097/wnr.0b013e32836164b4

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…Although we did not include a sham-injured group in this comparison, results show that only the CN2097-treated rats were able to significantly detect the complex tone reversal, reinforcing the significant treatment effect. These findings parallel reports of impaired event-related potential activity and central auditory acuity in TBI patients 34 , 55 – 57 .…”

Section: Discussionsupporting

confidence: 87%

TrkB-enhancer facilitates functional recovery after traumatic brain injury

Marshall

Szmydynger‐Chodobska

Rioult-Pedotti

et al. 2017

Sci Rep

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Brain-derived neurotrophic factor (BDNF), a key player in regulating synaptic strength and learning, is dysregulated following traumatic brain injury (TBI), suggesting that stimulation of BDNF signaling pathways may facilitate functional recovery. This study investigates whether CN2097, a peptidomimetic ligand which targets the synaptic scaffold protein, postsynaptic density protein 95, to enhance downstream signaling of tropomyosin-related kinase B, a receptor for BDNF, can improve neurological function after TBI. Moderate to severe TBI elicits neuroinflammation and c-Jun-N-terminal kinase (JNK) activation, which is associated with memory deficits. Here we demonstrate that CN2097 significantly reduces the post-traumatic synthesis of proinflammatory mediators and inhibits the post-traumatic activation of JNK in a rodent model of TBI. The recordings of field excitatory post-synaptic potentials in the hippocampal CA1 subfield demonstrate that TBI inhibits the expression of long-term potentiation (LTP) evoked by high-frequency stimulation of Schaffer collaterals, and that CN2097 attenuates this LTP impairment. Lastly, we demonstrate that CN2097 significantly improves the complex auditory processing deficits, which are impaired after injury. The multifunctionality of CN2097 strongly suggests that CN2097 could be highly efficacious in targeting complex secondary injury processes resulting from neurotrauma.

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Section: Discussionsupporting

confidence: 87%

TrkB-enhancer facilitates functional recovery after traumatic brain injury

Marshall

Szmydynger‐Chodobska

Rioult-Pedotti

et al. 2017

Sci Rep

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“…Auditory attention seems more challenging than visual attention in patients with ABI 18 , 19 . For example, individuals with ABI are incapable of focusing their attention to relevant auditory information.…”

Section: Introductionmentioning

confidence: 96%

High Oxygen Exchange to Music Indicates Auditory Distractibility in Acquired Brain Injury: An fNIRS Study with a Vector-Based Phase Analysis

Jeong

Ryu

Shin

et al. 2018

Sci Rep

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Attention deficits due to auditory distractibility are pervasive among patients with acquired brain injury (ABI). It remains unclear, however, whether attention deficits following ABI specific to auditory modality are associated with altered haemodynamic responses. Here, we examined cerebral haemodynamic changes using functional near-infrared spectroscopy combined with a topological vector-based analysis method. A total of thirty-seven participants (22 healthy adults, 15 patients with ABI) performed a melodic contour identification task (CIT) that simulates auditory distractibility. Findings demonstrated that the melodic CIT was able to detect auditory distractibility in patients with ABI. The rate-corrected score showed that the ABI group performed significantly worse than the non-ABI group in both CIT1 (target contour identification against environmental sounds) and CIT2 (target contour identification against target-like distraction). Phase-associated response intensity during the CITs was greater in the ABI group than in the non-ABI group. Moreover, there existed a significant interaction effect in the left dorsolateral prefrontal cortex (DLPFC) during CIT1 and CIT2. These findings indicated that stronger hemodynamic responses involving oxygen exchange in the left DLPFC can serve as a biomarker for evaluating and monitoring auditory distractibility, which could potentially lead to the discovery of the underlying mechanism that causes auditory attention deficits in patients with ABI.

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“…Only 3 studies have been published and the findings are mixed (one showing a deficit, one showing normal response, and one showing increased MMN compared to healthy controls). [23][24][25] Recently, MMN methodology has been optimized to better assess predictive coding by using a "roving" type of MMN paradigm (rMMN), in which the deviant stimulus becomes the standard stimulus until the next deviant which, in turn, becomes the new standard. [26][27][28] With the rMMN, one can assess changes in amplitude separately for standard, deviant, and the deviant-standard waveforms as the number of standard stimuli increases.…”

Section: Introductionmentioning

confidence: 99%

An EEG-Based Neuroplastic Approach to Predictive Coding in People With Schizophrenia or Traumatic Brain Injury

Wynn,

Green

2024

Clin EEG Neurosci

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Despite different etiologies, people with schizophrenia (SCZ) or with traumatic brain injury (TBI) both show aberrant neuroplasticity. One neuroplastic mechanism that may be affected is prediction error coding. We used a roving mismatch negativity (rMMN) paradigm which uses different lengths of standard tone trains and is optimized to assess predictive coding. Twenty-five SCZ, 22 TBI (mild to moderate), and 25 healthy controls were assessed. We used a frequency-deviant rMMN in which the number of standards preceding the deviant was either 2, 6, or 36. We evaluated repetition positivity to the standard tone immediately preceding a deviant tone (repetition positivity [RP], to assess formation of the memory trace), deviant negativity to the deviant stimulus (deviant negativity [DN], which reflects signaling of a prediction error), and the difference wave between the 2 (the MMN). We found that SCZ showed reduced DN and MMN compared with healthy controls and with people with mild to moderate TBI. We did not detect impairments in any index (RP, DN, or MMN) in people with TBI compared to controls. Our findings suggest that prediction error coding assessed with rMMN is aberrant in SCZ but intact in TBI, though there is a suggestion that severity of head injury results in poorer prediction error coding.

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Mismatch negativity abnormality in traumatic brain injury without macroscopic lesions on conventional MRI

Cited by 7 publications

References 23 publications

TrkB-enhancer facilitates functional recovery after traumatic brain injury

TrkB-enhancer facilitates functional recovery after traumatic brain injury

High Oxygen Exchange to Music Indicates Auditory Distractibility in Acquired Brain Injury: An fNIRS Study with a Vector-Based Phase Analysis

An EEG-Based Neuroplastic Approach to Predictive Coding in People With Schizophrenia or Traumatic Brain Injury

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