Mise en Evidence de la Carcinine Synthétase, une Nouvelle Enzyme Catalysant le Métabolisme de l'Histamine dans le Systeme Nerveux Central de Carcinus maenas
Abstract:Carcinine biosynthesis was induced in vitro from its two components, beta-alanine and histamine. The reaction was catalyzed by muscle, heart, and CNS extracts from Carcinus maenas. The specific activity of the enzyme, carcinine synthetase, was 15 times higher in CNS than in other organs. Only CNS extracts induced biosynthesis of carcinine from histidine, and only in the presence of pyridoxal-5'-phosphate. Hence the seat of carcinine biosynthesis seems to be the CNS. It is highly probable that in the CNS, histi… Show more
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