Mise au point sur la prise en charge chirurgicale du mélanome malin cutané. Revue de la littérature

Lavie, A.; Desouches, C.; Casanova, D.; Bardot, J.; Grob, Jean-Jacques; Legré, R.; Magalon, G.

doi:10.1016/j.anplas.2006.08.004

Cited by 13 publications

(3 citation statements)

References 105 publications

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“…Surgery is the most effective alternative for patients with early primary lesions whereas survival is dependent on the diagnostic stage of melanoma []. For patients with malignant melanoma, surgery is also the most essential treatment []. Other medical measures such as chemotherapy and cytokine therapy have also been investigated.…”

Section: Introductionmentioning

confidence: 99%

Proteomic investigation of anti‐tumor activities exerted by sinularin against A2058 melanoma cells

Su¹,

Lin

Chiu

et al. 2012

Electrophoresis

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The extracts from soft corals have been increasingly investigated for biomedical and therapeutic purposes. The aim of this study is to examine and analyze the anti-tumor effects of the genus Sinularia extract sinularin on A2058 melanoma cells using MTT assay, cell migration assay, wound healing assay, flow cytometric analysis, and proteomic analysis. Sinularin dose-dependently (1-5 μg/mL) inhibited melanoma cell proliferation while the treatment at identical concentrations suppressed cell migration. Sinularin dose-dependently enhanced apoptotic melanoma cells and caused tumor cell accumulation at G2/M phase, indicating that sinularin exerts apoptosis-induced and cell cycle-delayed activities in A2058 melanoma cells. Comparative proteomic analysis was conducted to investigate the effects of sinularin at the molecular level by comparison between the protein profiling of melanoma cells treated with sinularin and without the treatment. Thirty-five differential proteins (13 upregulated and 22 downregulated) concerning the treatment were identified by liquid chromatography-tandem mass spectrometry. Proteomic data and Western blot displayed the levels of several tumor inhibitory or apoptosis-associated proteins including annexin A1, voltage-dependent anion-selective channel protein 1 and prohibitin (upregulated), heat shock protein 60, heat shock protein beta-1, and peroxiredoxin-2 (downregulated) in A2058 melanoma cells exposed to sinularin. Increased expression of p53, cleaved-caspase-3, cleaved-caspase-8, cleaved-caspase-9, p21, and Bax and decreased expression of Bcl-2 in sinularin-treated melanoma cells suggest that the anti-tumor activities of sinularin against melanoma cells are particularly correlated with these pro-apoptotic factors. These data provide important information for the mechanisms of anti-tumor effects of sinularin on melanoma cells and may be helpful for drug development and progression monitoring of human melanoma.

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Section: Introductionmentioning

confidence: 99%

Proteomic investigation of anti‐tumor activities exerted by sinularin against A2058 melanoma cells

Su¹,

Lin

Chiu

et al. 2012

Electrophoresis

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“…The frequent location of LM in the head and neck area can present an esthetic challenge to the dermatologic surgeon, who must obtain complete clearance of the tumor while seeking to minimize the surgical defect. The classic surgical excision with a 5‐mm safety margin leads to a high rate of recurrence in 8–20% of cases, because LM lesions frequently exhibit significant subclinical spread …”

Section: Introductionmentioning

confidence: 99%

The “collerette” technique for skin excision and biopsy: an efficient method for managing lentigo maligna of the head and neck

2013

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“…[13] underligned that the surgical act is an essential part of the curative therapy, the biopsy should be complete to assess the level of underlying involvement. Surgery, as the only curative treatment cannot be considered in our setting due to the delay in diagnostic.…”

Section: Journal Of Cancer Science and Clinical Oncologymentioning

confidence: 99%

Palmoplantar Malignant Melanoma in the Brazzaville University Hospital

J¹,

Avm²,

Rb³

et al. 2017

Journal of Cancer science and Clinical Oncology

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Mise au point sur la prise en charge chirurgicale du mélanome malin cutané. Revue de la littérature

Cited by 13 publications

References 105 publications

Proteomic investigation of anti‐tumor activities exerted by sinularin against A2058 melanoma cells

Proteomic investigation of anti‐tumor activities exerted by sinularin against A2058 melanoma cells

The “collerette” technique for skin excision and biopsy: an efficient method for managing lentigo maligna of the head and neck

Palmoplantar Malignant Melanoma in the Brazzaville University Hospital

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