Mise au point d’une nouvelle méthode de perfusion en radiothérapie interne vectorisée du 177 lu-dotatate

Pesque, Raphaelle; Veyrier, Marc; Legrand, J; Lebtahi, Rachida; Pons‐Kerjean, Nathalie; Reguiga, Makrem Ben

doi:10.1016/j.phclin.2016.01.065

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“…In a similar way, another study presenting the development of a comparable delivery method for 177 Lu-Dotatate studied various pump/tubing couples and highlighted several difficulties such as flow issues, leaks, excessive tubing length or inappropriate spike size 9. Interestingly, this latter technique used a 2-way infusion set that allowed to rinse with saline a part of the line without disconnecting the 177 Lu-Dotatate vial during the injection process.…”

Section: Discussionmentioning

confidence: 99%

¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

et al. 2022

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Objectives177Lu-oxodotreotide (Lutathera) is an intravenous peptide receptor radionuclide therapy to treat unresectable metastatic digestive neuroendocrine tumours. The recommended method for Lutathera administration is gravity infusion; however, other appropriate and safe techniques are possible. This work compares two infusion methods from a medico-economic, radiation protection, efficiency and practicality point of view.MethodsTwo infusion methods were studied, either involving a volumetric infusion pump (method 1) or a peristaltic pump (method 2). For each method, the mean residual activity per vial and the mean injection time were compared. Occupational radiation exposure was measured. The cost of initial equipment and consumables for one administration was determined. Feedback from operators and past incidents during injections were collected through a survey.ResultsThree operators performed 219 Lutathera injections over 70 months: 60.7% (133) with method 1 and 39.3% (86) with method 2. After infusion, the mean residual activity in vial was 124.3±16.9 MBq with method 1 and 80.9±19.3 MBq with method 2 (34.9% decrease). The average administration time was 41±7.2 min with method 1 and 39±8.5 min with method 2. Occupational exposures obtained with both methods were very low and quite similar. Method 1 required an initial investment of 1165.8 US$ plus 4.0 US$ of supplies for each administration. Initial investment for method 2 was comparable (1261.4 US$) but supplies cost per administration was higher (12.5 US$). Two major incidents were recorded with method 1 and none with method 2. From operators' experience, method 2 felt safer and more suitable.ConclusionsMethod 2 appeared to be convenient and secure, despite a higher cost per injection. It could also be applied to new radioligand therapies such as 177Lu-PSMA or 225Ac-Dotatate.

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Section: Discussionmentioning

confidence: 99%

¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

et al. 2022

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Mise au point d’une nouvelle méthode de perfusion en radiothérapie interne vectorisée du 177 lu-dotatate

Cited by 1 publication

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¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

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Mise au point d’une nouvelle méthode de perfusion en radiothérapie interne vectorisée du 177 lu-dotatate

Cited by 1 publication

References 0 publications

177Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

177Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

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¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods

¹⁷⁷Lu-Dotatate administration using an infusion pump or a peristaltic pump: comparison of two methods