Miscibility study of chitosan/2-hydroxyethyl starch blends and evaluation of their effectiveness as drug sustained release hydrogels

Nanaki, Stavroula; Koutsidis, Ioannis A.; Koutri, Ioanna; Karavas, Evangelos; Bikiaris, Dimitrios N.

doi:10.1016/j.carbpol.2011.09.013

Cited by 47 publications

(18 citation statements)

References 40 publications

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“…It was found that the drug delivery membrane was effective on permeability, swelling property, and release of mitomycin C in vitro. In our another early work, we developed a novel membrane consisting of HE-chitosan, gelatin and chondroitin sulfate, and found that it could be potentially used as a carrier for corneal endothelial cell transplantation Zhao et al, 2008;Nanaki et al, 2012). However, the biosafety of HE-chitosan has rarely been studied though it is important for its applications.…”

Section: Discussionmentioning

confidence: 98%

“…In addition, HE-chitosan is a natural polysaccharide derived from chitosan with features of the extracellular matrix (ECM), and has the potential of directing cell migration, growth and organization Zhao et al, 2008;Nanaki et al, 2012). However, the absorption and distribution of HE-chitosan in vivo are also critical for its medical and clinical applications, which still need further study.…”

Section: Discussionmentioning

confidence: 99%

“…Its intermolecular forces are weakened, the water-solubility is increased, and moisturizing property is improved. Particularly, HE-chitosan can effectively inhibit the growth of microorganisms by combining with DNA Zhao et al, 2008;Nanaki et al, 2012). Additionally, it is chemically and enzymatically modifiable and easy to develop into various forms Zhao et al, 2008;Nanaki et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…In our previous works, a novel drug loaded membrane made of N-succinyl-hydroxyethyl chitosan and mitomycin C has been employed as an implant for glaucoma filtering surgery Zhao et al, 2008;Nanaki et al, 2012). It was found that the drug delivery membrane was effective on permeability, swelling property, and release of mitomycin C in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…HE-chitosan is a multifunctional derivative of chitosan with good water-solubility Zhao et al, 2008;Nanaki et al, 2012). The introduction of hydroxyethyl group improves the spatial structure, weakens the intermolecular forces and increases the water-solubility thus improving the moisturizing property of HE-chitosan (Wan et al, 2004;Xie et al, 2007;Yu et al, 2010).…”

Section: Introductionmentioning

confidence: 95%

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Synthesis and characterization of a hydroxyethyl derivative of chitosan and evaluation of its biosafety

Shao

Han

Gao

et al. 2015

J. Ocean Univ. China

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Hydroxyethyl chitosan (HE-chitosan) is a water-soluble derivative of chitosan with many apparent biological properties. For example, it is non-toxic and rapidly biodegradable. Moreover, HE-chitosan has advantages in water-solubility, moisture retention and gelling property due to its hydroxyethyl group. However, the biocompatibility and biodegradability of this multifunctional derivative have rarely been documented although they are critical for its application in biomedical and clinical treatments. The purpose of this work was to evaluate the biosafety of HE-chitosan, and draw important clues for its diverse applications. HE-chitosan was synthesized and characterized its chemical structure with FTIR. Its molecular weight (M W ) was determined by gel permeation chromatography (GPC), and its deacetylation degree (DD) was investigated through potentiometric analysis. The cytotoxicity of HE-chitosan on mouse fibroblast cell L929 was tested. The biocompatibility and biodegradability of HE-chitosan in rat and rabbit were evaluated. The FTIR results indicated that the hydroxyethyl groups were linked to C 6 of chitosan. The GPC analysis confirmed that its Mw was about 90.01 kDa. It was also demonstrated that HE-chitosan had excellent biocompatibility and biodegradability in vivo and had no cytotoxicity on L929. These findings indicated that HE-chitosan can potentially be applied as a biomaterial in tissue engineering, drug delivery, and other biomedical fields.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 3 more Smart Citations

Synthesis and characterization of a hydroxyethyl derivative of chitosan and evaluation of its biosafety

Shao

Han

Gao

et al. 2015

J. Ocean Univ. China

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Biomedical Applications of Chitosan and Its Derivatives

Malhotra,

Gautam

2024

Biopolymers for Biomedical Applications

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Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

Zhu

Mao

Cheng

et al. 2019

Adv Materials Inter

254

142

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Polysaccharide is an abundant and reproducible natural material that is biocompatible and biodegradable. Polysaccharide and its derivatives also possess distinctive properties such as hydrophilicity, mechanical stability, as well as tunable functionality. Polysaccharide‐based hydrogels can be constructed via the physical and/or chemical crosslinking of polysaccharide derivatives with different functional molecules, as porous network structures or nanofibrillar structures. This review discusses the biomedical applications of polysaccharide‐based hydrogels containing native polysaccharides, polysaccharide derivatives, and polysaccharide‐composite hydrogels. Recent works on the fabrication, physical properties, advanced engineering, biomedical applications of cellulose‐, chitosan‐, alginate‐, and starch‐based hydrogels are also elaborated. Such porous swelling scaffolds exhibit great advantages at the interface of a negative pressure system such as wound dressing. In addition, the authors also discuss and summarize the exemplary research works of these hydrogels in the applications of drug release, wound dressing, and tissue engineering. Finally, challenges and future perspectives about the development of polysaccharide‐based hydrogels are discussed.

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Miscibility study of chitosan/2-hydroxyethyl starch blends and evaluation of their effectiveness as drug sustained release hydrogels

Cited by 47 publications

References 40 publications

Synthesis and characterization of a hydroxyethyl derivative of chitosan and evaluation of its biosafety

Synthesis and characterization of a hydroxyethyl derivative of chitosan and evaluation of its biosafety

Biomedical Applications of Chitosan and Its Derivatives

Recent Progress of Polysaccharide‐Based Hydrogel Interfaces for Wound Healing and Tissue Engineering

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