Miscibility and sustained release of drug from cellulose acetate butyrate/caffeine films

Furtado, Laíse M.; Hilamatu, Karina C. P; Krishnasamy, Balaji; Ando, Rômulo Augusto; Petri, Denise Freitas Siqueira

doi:10.1016/j.jddst.2019.101472

Cited by 7 publications

(7 citation statements)

References 37 publications

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“…SEM images show needle-shaped crystals (10-15 µm) of caffeine grown on cell walls after the evaporation of distilled water. As described by Furtado et al (2020), the crystallization effect is related to the self-organization of caffeine molecules through the π-stacking interaction effect [54]. The SEM observations suggest that caffeine tends to fill intercellular spaces.…”

Section: Computational Studiesmentioning

confidence: 64%

“…In the literature, there are interesting reports on the applications of cellulose and caffeine in the biomedical and cosmetic areas. Due to the properties of caffeine such as the ability to swell, biocompatibility, and nontoxicity, polysaccharides including cellulose have been often used to encapsulate caffeine [54]. Caffeine is a broadly studied drug that contributes to the fast release and weak interactions of bio-cellulose nanofibrils [39].…”

Section: Computational Studiesmentioning

confidence: 99%

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Chemical Changes of Wood Treated with Caffeine

et al. 2021

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Earlier studies have revealed that wood treated with caffeine was effectively protected against decay fungi and molds. However, there is a need to establish how the caffeine molecule behaves after wood impregnation and how it can protect wood. The objective of the research was to characterize the interaction between caffeine and Scots pine (Pinus sylvestris L.) wood as well as to assess the stability of the alkaloid molecule in lignocellulosic material. For this purpose, an elementary analyzer was used to assess the nitrogen concentration in the treated wood. The results showed that caffeine is easily removed from the wood structure through large amounts of water. The changes occurring in the wood structure after impregnation were evaluated with regard to the results obtained by Fourier transform infrared (FTIR) spectroscopy of two model mixtures with caffeine and cellulose or lignin for the purpose of conducting a comparison with the spectrum of impregnated and non-impregnated samples. The observed changes in FTIR spectra involve the intensity of the C=O(6) caffeine carbonyl group and signals from guaiacyl units. It might indicate favorable interactions between caffeine and lignin. Additionally, molecular simulation of the caffeine’s interaction with the guaiacyl β-O-4 lignin model compound characteristic for the lignin structure using computational studies was performed. Consequently, all analyses confirmed that caffeine may interact with the methylene group derived from the aromatic rings of the guaiacyl group of lignin. In summary, scanning electron microscope (SEM) observations suggest that caffeine was accumulated in the lignin-rich areas of the primary walls.

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Section: Computational Studiesmentioning

confidence: 64%

Section: Computational Studiesmentioning

confidence: 99%

Chemical Changes of Wood Treated with Caffeine

et al. 2021

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“…Caffeine in various mixtures has alre been tested [9,20,21]. However, there are no studies about the chemical interactions of caffeine and i vidual primary wood structures, with the exception of caffeine as drug-coated cellu wrapping [22]. For this reason, in this study, we separately analyzed caffeine interact with basic wood components such as cellulose; hemicellulose; and lignin and its pre sors conipheryl alcohol, sinapyl alcohol, and coumaryl alcohol separately as aquatic s tions in the present study.…”

Section: Ofmentioning

confidence: 99%

Caffeine Interactions with Wood Polymers

Kobetičová

Ďurišová

Nábělková

2021

Forests

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Caffeine is a verified bioactive substance suitable for wood protection against pests. Unlike studies of the biocidal effects of caffeine, caffeine-wood bonds and interactions with wood polymer structures have not been studied whatsoever thus far. For this reason, caffeine (1 g/L) interactions with the main wood components (cellulose; hemicellulose; lignin and its precursors conipheryl alcohol, sinapyl alcohol, coumaryl alcohol) were analyzed in the present study. Caffeine concentrations were analyzed using UV–VIS spectrometry at wavelength 287 nm. The results confirmed caffeine variable binding with wood components in comparison to controls (pure caffeine). Cellulose and sinapyl alcohol did not interact with caffeine. Caffeine was bonded with the rest of the wood components in an increasing rank: conipheryl alcohol = lignin < hemicellulose < coumaryl alcohol. These results have a significant role in the protection of wood depending on its chemical composition and the wood species.

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“…The porous structure indicated by white arrows was possibly due to the evaporation of acetone during the drying process. The sponge structure is also known as "breath-figure" structures on the surface obtained from the evaporation of the solvent droplets on cellulose acetate-glycerol (as plasticizer) solution of the film (Furtado et al, 2020;Kalaycıoğlu et al, 2020). The smoother surface and low porosity in the film containing ground mustard seeds are in line with the results obtained by Rajeswari et al (2020), who investigated the effect of the addition of polysaccharide (fine powder of sodium alginate and carrageenan)…”

Section: Thickness Morphology Of the Film And Distribution Of Ground Seeds In The Filmsupporting

confidence: 53%

Antimicrobial packaging design : Exploring the potential of allyl isothiocyanate release from mustard seeds

Bahmid¹

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Table of Contents Chapter 1. General Introduction Chapter 2. Using particle size and fat content to control the release of Allyl isothiocyanate from ground mustard seeds for its application in antimicrobial packaging Chapter 3. Multiresponse kinetic modelling of the formation, release, and degradation of allyl isothiocyanate from ground mustard seeds to improve active packaging Chapter 4. Modelling the effect of food composition on antimicrobial compound absorption and degradation in an active packaging Chapter 5. Packaging design using mustard seeds as a natural antimicrobial: A study on inhibition of Pseudomonas fragi in liquid medium Chapter 6. Development of a moisture-activated antimicrobial film containing ground mustard seeds and its application on meat

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Miscibility and sustained release of drug from cellulose acetate butyrate/caffeine films

Cited by 7 publications

References 37 publications

Chemical Changes of Wood Treated with Caffeine

Chemical Changes of Wood Treated with Caffeine

Caffeine Interactions with Wood Polymers

Antimicrobial packaging design : Exploring the potential of allyl isothiocyanate release from mustard seeds

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