Miscellaneous Tumors and Tumor-Like Proliferations of the Lung

Fraire, Armando E.; Dail, David H.

doi:10.1007/978-0-387-72114-9_10

Cited by 3 publications

(2 citation statements)

References 152 publications

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“…40 Papillary adenomas (bronchiolar papillomas) of man may have focal sclerosis but are not generally diffusely sclerotic. 16 By immunohistochemistry, those tumors are positive for thyroid transcription factor-1 and surfactant apoproteins A and B. Because the tumors in this series were so small and lost on recuts, immunohistochemistry was not performed.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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Spontaneous age-related lesions of laboratory rabbits are not well documented in the contemporary scientific literature. A retrospective study of diagnostic necropsies of 36 rabbits >2 years of age found a number of common lung lesions. Fibromuscular intimal hyperplasia affected medium and to a lesser extent large pulmonary arteries and was present to a variable extent in all 36 rabbits >2 years of age. The lesions were characterized by fragmentation and/or reduplication of the internal elastic lamina (IEL), proliferation of smoothelinþ/alpha-smooth muscle actin (a-SMA)þ/vimentinÀ smooth muscle cells and fewer smoothelinÀ/a-SMAþ/vimentinþ myofibroblasts, and intimal deposition of collagen without thrombosis, embolism, or evidence of pulmonary hypertension. Pulmonary emphysema, present in 30/36 rabbits, was characterized by the loss of alveolar septa; most affected rabbits did not have clinical signs of respiratory disease. In 8/13 rabbits of the inbred EIII/JC audiogenic strain, we identified a unique syndrome of granulomatous pneumonia containing hyaline brown to gray, globular to ring-like acellular material that was Alcian blue and periodic acid-Schiff positive. The material was immunoreactive for surfactant protein-A and had the ultrastructural appearance of multilamellar vesicles, suggesting a genetic defect in surfactant metabolism. Additionally, we found small benign primary lung tumors (fibropapillomas, 5 rabbits) not previously described. Other findings included heterotopic bone (5 rabbits), subacute to chronic suppurative bronchopneumonia, pyogranulomatous pneumonia with plant material, and pulmonary artifacts from barbiturate euthanasia solution.Although spontaneous background lesions of aging laboratory mice and rats are well documented and described, 7,9,19,23,31 there is less information on spontaneous lesions of aging laboratory rabbits. 14,15,21 In part this is because of the types of acute or relatively short-term studies for which rabbits are commonly used. In some cases where age-related lesions are described, such as spontaneous pulmonary emphysema, 42 other more recent references are contradictory, based apparently on the lack of additional confirmatory reporting. 4,8 Other spontaneous age-related lesions, such as unique intimal proliferations in the pulmonary arteries, are poorly documented in the English language literature, 20 and can resemble iatrogenic lesions caused by experimental manipulation. 27 While most rabbits used in research are outbred New Zealand White (NZW) or Dutch-belted stock, inbred rabbits strains do exist, including the audiogenic (EIII/JC) strain. The inbred III/J parent rabbit strain was originally developed at the Jackson Laboratory in 1932 by Dr Paul B. Sawin using NZW rabbits from Dr William Ernest Castle. The audiogenic (EIII/J) substrain was selected for a predisposition to sound-induced seizures by Dr Richard R. Fox in 1961. 13 The strain came to Penn State Hershey in 1988 from the National Cancer Institute. 37 Rabbits have been used as an induced experimental...

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Section: Discussionmentioning

confidence: 99%

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

et al. 2016

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“…1 The median age is 45 years, with a range of 2 to 83 years. 1 The median age is 45 years, with a range of 2 to 83 years.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing Hemangioma of the Lung

Roggli¹,

Pavlisko²,

Seaman³

2012

Pathology Case Reviews

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Sclerosing hemangioma of lung is an unusual neoplasm with distinctive morphological features. Although its histogenesis has been debated for decades, the current concept is that this is a tumor of cells with features most closely resembling type II pneumocytes. The tumor has 2 separate cellular components (surface cells and round cells) and 4 different growth patterns (solid, papillary, sclerotic, and hemorrhagic), which may be present in various degrees from one tumor to another. Both surface and round cells stain positive for TTF-1 and epithelial membrane antigen, whereas the surface cells stain strongly positive for cytokeratins and for surfactant proteins A and B. Round cells generally stain negative for cytokeratins and surfactant proteins. Ultrastructurally, the surface cells have features of type II pneumocytes with well-formed lamellar bodies, whereas the round cells are more primitive and contain dense core granules and microtubules. Despite the name of the tumor, vascular differentiation is not observed. Sclerosing hemangioma typically presents as a unilateral pulmonary nodule, but multiple and bilateral examples have been reported. Although this tumor typically behaves in a benign fashion with long-term survival expected after surgical resection, cases with lymph node metastases and more aggressive clinical behavior have been reported. This tumor has the potential for confusion with other more common and aggressive lung neoplasms, especially in cytological specimens. We report herein a case of sclerosing hemangioma of the lung with lymph node metastasis and review the literature on this unusual neoplasm.

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Carcinoma of the Lung

Roggli

2013

Pathology of Asbestos-Associated Diseases

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Miscellaneous Tumors and Tumor-Like Proliferations of the Lung

Cited by 3 publications

References 152 publications

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

Spontaneous Lung Lesions in Aging Laboratory Rabbits (Oryctolagus cuniculus)

Sclerosing Hemangioma of the Lung

Carcinoma of the Lung

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